慢性阻塞性肺疾病稳定期患者下呼吸道细菌定植及对血清TNF-α、IL-8的影响  

Relationship between lower airway bacterial colonization and serum TNF-α and IL-8 in patients with stable chronic obstructive pulmonary disease

作　　者：莫伟强[1] 

机构地区：[1]嘉兴市第二医院呼吸内科,314000

出　　处：《国际呼吸杂志》2013年第10期739-741,共3页International Journal of Respiration

摘　　要：目的探讨慢性阻塞性肺疾病（c0PD）稳定期患者下呼吸道细菌定植（LABc）与炎症反应的关系。方法选择62例COPD稳定期患者，留取痰液标本并进行培养，检测患者血清肿瘤坏死因子α（TNF—α）、白介素8（IL-8）水平，对患者进行肺功能测定。结果62例患者中有18例（29．03％）患者存在I，ABC，存在LABC患者血清TNF-α、IL-8水平高于无LABC者（P〈0．05）；存在LABC者肺功能FEV1％precl、FEV1／FVC低于无LABC者，吸烟指数≥400的比例大于无LABC者，差异均有统计学意义（P〈O．05）；LABc定量培养结果与TNF-α及IL-8水平呈正相关（P〈O．05）。结论部分c0PD稳定期患者存在LABC，而LABC可加重患者炎症反应，加剧肺功能的损害。Objective To explore the relationship between lower airway bacterial colonization （LABC） and inflammatory response in patients with stable chronic obstructive pulmonary disease （COPD）. Methods 62 patients with stable COPD were chosen, the sputum specimens were cultured, and serum tumor necrosis faetor-α （TNF-α） and interlukin-8 （IL-8） as well as lung function were detected. Results In 62 cases, 18 cases （29.03%） had LABC. Serum TNF-α and IL-8 levels in LABC patients were higher than those without LABC （P〈0.05）. FEV1% pred, FEV1/FVC were lower, and the proportion of smoking index ≥400 was higher in LABC patients than those without LABC （ P 〈0.05）. The LABC quantitative culture results was positively correlated with TNF-α and IL-8 levels （ P〈0.05）. Conclusions Some stable COPD patients exist LABC which can aggravate the inflammatory reaction and damage the lung function.

关 键 词：慢性阻塞性肺疾病 下呼吸道细菌定植 炎症介质 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]