无症状性高尿酸血症与代谢综合征及其组分相关性的研究  

Association of asymptomatic hyperuricemia with metabolic syndrome and its components

作　　者：梁凯[1] 曲勇[2] 邓楠[1] 侯新国[1] 武传龙[1] 孙宇[1] 宋君[1] 林鹏[1] 陈丽[1] 

机构地区：[1]山东大学齐鲁医院内分泌科,济南250012 [2]山东铝业公司医院内分泌科

出　　处：《中国糖尿病杂志》2013年第5期388-391,共4页Chinese Journal of Diabetes

基　　金：中华医学会糖尿病学分会重点项目(07020470055);国家科技支撑计划项目(2009BAI80B04);山东省自然科学基金(Z2008C05);山东省科技攻关国际科技合作项目(2010GHZ20201);山东大学自主创新基金(2009TS054)

摘　　要：目的调查无症状性高尿酸血症(HUA)的患病特点,探讨血尿酸(SUA)水平与MS及其组分的相关性。方法通过随机整群抽样,对301名山东铝业公司职工进行调查与体检,并进行血液检查,根据SUA水平分为高尿酸血症(HUA)组与正常尿酸(NUA)组。结果 HUA总检出率为22.3%,男性高于女性(P<0.01);MS检出率为25.2%,其组分超重或肥胖、高血糖、高血压、血脂异常的检出率分别为59.8%、18.9%、36.2%、34.9%,而HUA组MS及超重或肥胖、高血糖、高血压、血脂异常的检出率均高于NUA组(P<0.05);HUA组中具有2个及以上MS组分数目的患者多于NUA组(P<0.01);SUA水平与BMI、WC、SBP、TC、TG、LDL-C呈正相关,与HDL-C呈负相关;WC(OR:1.111,95%CI:1.053～1.172)、TG(OR:1.288,95%CI:1.015～1.634)、LDL-C(OR:1.739,95%CI:1.200～2.519)是发生HUA的相关因素。结论 SUA水平与MS及其组分密切相关,其中WC、TG与LDL-C是发生HUA的相关因素。Objective To investigate the characteristics of asymptomatic hyperuricemia （HUA）, and evaluate the association of serum uric acid （SUA） level with MS and its components. Methods A random cluster sampling was conducted in 301 employees of Shandong Aluminum Company. The subjects received physical and serological examinations. Hyperuricemia was defined as ≥417 μtmol/L （in men） and ≥357 tmaol/L （in women）. MS was defined using the recommendation of CDS in 2004. Available data was analyzed using SPSS 18. 0 statistical software, and the difference was statistically significant when P〈0. 05. Results Total detection rate of HUA was 22.3%, and significantly higher in male than in female. （P〈0. 0t）. The detection rate of MS was 25.2%, and the detection rate of overweight or obese, hyperglycemia, hypertension, and dyslipidemia in HUA patients was 59.8%, 18.9%, 36.2%, and 34. 9% respectively, all higher than that in the NUA group （all P〈0. 05）. The patients having two or more components of MS in HUA group were significantly more than those in NUA group （P〈0. 01）. SUA level was positively correlated with BMI, WC, SBP, TC, TG, and LDL-C, and negatively correlated with HDL-C. The relevant factors of HUA were WC （OR ：1. 111, 95%CI ： 1. 053%1. 172）, TG （OR ： 1.288, 95%CI ： 1.015-1.634）, and LDL-C （OR ： 1.739, 95-CI ： 1. 200-2. 519）. ConclusionIncreased serum uric acid level is associated with an increased prevalence of metabolic syndrome and its components, and WC, TG, and LDL-C are the relevant factors of HUA.

关 键 词：无症状性高尿酸血症 血尿酸 代谢综合征 

分 类 号：R589[医药卫生—内分泌]