糖尿病患者HDL亚类代谢异常的研究现状  

The research progress of metabolism abnormality of HDL subclasses in diabetes patients

作　　者：陶世冰[1] 田浩明[2] 

机构地区：[1]四川省资阳市第一人民医院内分泌代谢科,641300 [2]四川大学华西医院内分泌代谢科

出　　处：《中国糖尿病杂志》2013年第5期478-480,共3页Chinese Journal of Diabetes

摘　　要：糖尿病患者常合并脂代谢异常,主要表现为TG升高,HDL-C降低。研究显示,糖尿病患者HDL不仅数量减少,且质量也下降。HDL是一种高异质性的脂蛋白,利用不同方法可将HDL分为不同亚类。研究发现糖尿病患者血中成熟的HDL亚类减少,非成熟的亚类增加。导致患者抗动脉粥样硬化(AS)能力下降,这种改变的敏感性远高于HDL-C数量的变化。因此,关注糖尿病患者HDL亚类的代谢异常可将预防糖尿病AS防线进一步前移。Patients with diabetes have an increased prevalence of lipid abnormalities. Low levels of HDL cholesterol, often associated with elevated triglyceride levels, are the most prevalent pattern of dyslipidemia in diabetics. Meanwhile, some studies find that both the quantity and quality of HDL are decreased in diabetic patients. It is well known that HDL can be categorized into different subclasses by using different means. Studies show that the mature HDL subclasses are decreased and the non-mature subclasses are increased in diabetic patients. These changes will contribute to increasing the risk of artery atherosclerosis. Furthermore, the changes of HDL subclasses are more sensitive than decreasing of the quantity in HDL cholesterol. So if we pay more attention to the HDL subclasses changes, the earlier prevention of atherosclerosis will be made in clinical practice.

关 键 词：糖尿病 HDL亚类 

分 类 号：R587.1[医药卫生—内分泌]