石见穿化学成分研究  

Chemical constituents of Salvia chinensis

作　　者：高俊峰[1] 丁玲[1] 张鹏[1] 刘建勋[1] 

机构地区：[1]中国中医科学院西苑医院实验研究中心,北京100091

出　　处：《中国中药杂志》2013年第10期1556-1559,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81073060)

摘　　要：该实验针对石见穿醋酸乙酯部位化学成分进行研究。采用硅胶、ODS、Sephadex LH-20柱色谱和高效液相制备色谱进行分离纯化,运用NMR和MS等波谱学方法,并结合文献对照确定了化合物的结构。从石见穿醋酸乙酯部位中分离鉴定了11个化合物,分别为:oresbiusin A(1),ethyl dihydrocaffeate(2),迷迭香酸乙酯(3),迷迭香酸(4),迷迭香酸甲酯(5),bis(2-ethylhexyl)phthalate(6),丹酚酸C(7),丹酚酸C甲酯(8),丹酚酸A甲酯(9),紫草酸B二甲酯(10),丹酚酸A(11)。除迷迭香酸外,其他化合物均为首次从该植物中分离得到。Chemical constituents were investigated on the ethyl acetate extract of Salvia chinensis. Compounds were separated and purified by various chromatograhic techniques including silica gel, Sephadex LH-20 and reversed-phase HPLC. Their structures were identified by spectroscopic data analysis. Eleven compounds were isolated and purified and their structures were identified as ores- biusin A（ 1 ）, ethyl dihydrocaffeate （ 2 ）, ethyl rosmarinate （ 3 ）, rosmarinic acid （ 4 ）, methyl rosmarinate （ 5 ）, bis （ 2-ethylhexyl ） phthalate （6）, salvianol acid C （ 7 ）, methyl salvianol acid C （ 8 ）, methyl salvianolate A （ 9 ）, dimethyl lithospermate B （ 10 ）, and salvianolic acid A（ll ）. Except for rosmarinic acid, the remaining compounds were isolated from S. chinensis for the first time.

关 键 词：石见穿 唇形科 化学成分 

分 类 号：R284[医药卫生—中药学]