淫羊藿生品及不同炮制品小鼠药代动力学特征的比较研究  

Comparative study on effect of crude and different processed products of epimedium on pharmacokinetics characteristics in mice

作　　者：崔莉[1,2] 孙娥[1] 钱浅[1] 樊宏伟[3] 邹建军[3] 贾晓斌[1,2] 

机构地区：[1]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]南京中医药大学药学院,江苏南京210046 [3]南京医科大学附属南京第一医院临床药理实验室,江苏南京210006

出　　处：《中国中药杂志》2013年第10期1614-1617,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30973944;81274088);江苏省六大人才高峰项目(2009114);江苏省中医药科学技术项目(LZ09067)

摘　　要：淫羊藿生品及不同炮制品的提取物对小鼠体内药代动力学特征参数的影响不同。为探索其炮制用药的合理性,作者分别灌胃给小鼠淫羊藿生品、加热品以及羊脂油制品提取液,以超氧化物歧化酶(SOD)升高量为指标,采用药理效应法得到时间-体存生物相当药量的关系。由DAS 2.0软件分析,比较其药代动力学参数。结果表明,三者的达峰浓度Cmax、药时曲线下面积AUC等药动学特征参数均具有显著性差异,油制品>加热品>生品。从而得出淫羊藿经加热后生物利用度提高,而辅料羊脂油进一步促进其体内吸收这一结论。To study different impacts of crude epimedium and extracts from different processed epimedium on pharmacokinetic characteristic parameters in mice. To explore the rationality of its processed products, mice were orally administered with crude epime- dium and extracting solutions from heated epimedium and processed epimedium. With increased SOD value as an indicator, the rela- tionship between time and equivalent body dose was obtained by using the pharmacological effect method. DAS 2. 0 software was adopted to compare their pharmacokinetic parameters. The results showed significant differences in such pharmacokinetic parameters as Cmax and AUC of processed epimedium, heated epimedium and crude epimedium, namely processed epimedium 〉 heated epimedium 〉 crude epimedium. We could come to the conclusion that heated epimedium showed increased bioavailability, while epimedium pro- cessed with sheep oil could further promote in vivo absorption.

关 键 词：淫羊藿 炮制 药代动力学 药理效应法 

分 类 号：R285.5[医药卫生—中药学]