中药归经研究的现状及“穴药”法的提出  

Status of reaching meridian research for Chinese matria medica and to raise "point-medicine" method

作　　者：邓凯文[1] 贺福元[2] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南中医药大学药学院,中药药性与药效国家中医药管理局重点实验室,现代中药制剂制备技术与评价实验室,湖南长沙410208

出　　处：《中国中药杂志》2013年第10期1643-1648,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81073142,81173558);国家教育部博士点基金项目(20104323110002)

摘　　要：目的:分析中药归经研究的现状,提出并阐明"穴药"法的中药归经研究法。方法:对中药有效成分群(物)的归经及与经络脏腑功能(象)的互应关系的研究现状进行剖析,找出其不足与解决问题的对策。结果:特定的中药成分群对特定的经络脏腑有选择性的作用,这是中药归经的物质基础,体现"物"性;经络脏腑的功能状态以一定的证候表现出来,体现"象"性,一定功能的经络脏腑对特征中药成分群有反作用,可用于探知和表征经络脏腑,体现"候"性,三者实为"物-象-候"印迹关系。经络脏腑功能状态也可通过针刺特异腧穴改变,而这种改变可以通过中药定量药理学参数表征,据此可建立中药归经研究的"穴药"新方法,也可以探讨中药成分与病证网络靶点的关系,起到一箭双雕的作用。结论:中药与经络脏腑及其功能三者互为"物-象-候"印迹关系,可通过针刺特异性腧穴改变,"穴药"法既是中药归经研究最简捷的方法,也是探知经络脏象重要方法。Objective： To analyze the status of reaching meridian research for the Chinese Matria Medica and to raise point- medicine method. Method： To review and analyze the studied situation of the corresponding relationships between ＂materials＂ , as the constituents in the Chinese materia medica（CMM） as reaching meridian material foundation, and ＂ image＂ , as the function states of the zang-fu viscera, to investigate the problems and the measures to solve it. Result： There are imprinting relationships among ＂materi- als＂ , as the constituents alike metabolic pathway in the CMM as reaching meridian material foundation, and ＂image＂ , as the function of the zang-fu viscera related with meridians, and ＂symptom＂ , the states of them, retroacted, represented and explored by the corre- sponding meridianed constituents in the CMM as quantitative pharmacologic parameters, also modified by special acupuncture points, fi- nally to establish the new method of reaching meridian according to meridian point-medicine action and also to investigate the relations between the constituents in the CMM and network targets of disease as to kill two birds with one arrow. Conclusion： There are imprint- ing relationships among ＂materials＂ , ＂image＂ , ＂symptom＂ versus CMM, zang-fu viscera function related with meridians, their func- tion status respectively, which are modified by acupuncture merisian points. The point-medicine method for assuring reaching meridian is the most simple way to investigate reaching meridian for CMM,is also a important way to investigate visceral and meridianal manifestations.

关 键 词：中药归经 经络脏腑 证候 物-象-候 网络药理学 拓扑网络 网络谱效动力学 中药药性 中医药现代化 穴药 法 印迹 

分 类 号：R285.1[医药卫生—中药学]