与不对称二甲基精氨酸的合成、代谢、转运相关的心血管疾病潜在治疗靶点及药物  

Potential Therapeutic Targets for Cardiovascular Diseases in Synthesis,Metabolism and Transport of Asymmetric Dimethylarginine and the Related Drugs

作　　者：袁林华[1] 何华[1] 李辰[1] 马雪琴[1] 柳晓泉[1] 

机构地区：[1]中国药科大学药物代谢动力学研究中心,江苏南京210009

出　　处：《药学进展》2013年第5期199-206,共8页Progress in Pharmaceutical Sciences

摘　　要：不对称二甲基精氨酸是一种内源性的一氧化氮合酶抑制剂,与多种心血管疾病的发生、发展密切相关,是心血管疾病的危险因子。参与不对称二甲基精氨酸的合成、代谢和转运过程的相关酶和转运体或可成为心血管疾病的潜在治疗靶点。综述与不对称二甲基精氨酸的合成、代谢和转运相关的心血管疾病潜在治疗靶点及药物研究情况。As an endogenous nitric oxide synthase （NOS） competitive inhibitor, the asymmetric dime- thylarginine （ADMA） is related to the pathothysiological process of several cardiovascular diseases. It is also regarded as a novel cardiovascular risk factor. The enzymes and transporters related to ADMA synthesis, metabolism and transport processes may serve as potential therapeutic targets for cardiovascular diseases. The potential therapeutic targets in ADMA synthesis, metabolism and transport processes for cardiovascular diseases, and the research progresses of related drugs were reviewed in this paper.

关 键 词：不对称二甲基精氨酸 蛋白精氨酸甲基转移酶 二甲基精氨酸二甲胺水解酶 阳离子氨基酸转运体 心血管疾病 血管内皮功能障碍 

分 类 号：R54[医药卫生—心血管疾病]