中药对铂类抗肿瘤药物的减毒增效作用研究进展  

Advances in Research on the Effects of Traditional Chinese Medicines on Platinum Antitumor Drugs

作　　者：张培[1,2] 吕蒙莹[1,2] 刘劝[3] 白瑞珍[4] 张尊建[1,2] 许风国[1,2] 

机构地区：[1]中国药科大学药物分析教研室,江苏南京210009 [2]中国药科大学药物质量与安全预警教育部重点实验室,江苏南京210009 [3]无锡市第四人民医院肿瘤科,江苏无锡214062 [4]无锡市第四人民医院病理科,江苏无锡214062

出　　处：《药学进展》2013年第5期207-214,共8页Progress in Pharmaceutical Sciences

基　　金：江苏特聘教授计划;国家自然科学基金面上项目(No.81274108);江苏省自然科学基金青年基金项目(No.BK2012101)

摘　　要：铂配合物具有广谱抗肿瘤活性,在恶性肿瘤化疗中占有举足轻重的地位。但该类药物也存在肾毒性、胃肠道毒性、耳毒性、造血系统毒性和神经系统毒性等严重毒副作用,使其临床应用大大受限。近来研究表明,中药在防治化疗毒副作用和提高肿瘤细胞化疗敏感性等方面表现出明显优势。综述了中药对铂类抗肿瘤药物的减毒增效作用研究进展。Platinum complexes have a broad spectrum of antitumor activity and play an important role in the chemotherapy of malignant tumors. However, their clinical applications are limited due to the serious toxic and side effects such as nephrotoxicity, gastrointestinal toxicity, ototoxicity, hematopoietic system toxicity, nervous system toxicity, etc.. Recently, some Traditional Chinese Medicines show great potentials to enhance the efficacy and diminish the side effects when used in combination with platinum antitumor drugs. The advances in research on the effects of Traditional Chinese Medicines on platinum antitumor drugs were reviewed in this paper.

关 键 词：中药 铂类药物 化疗 减毒增效 

分 类 号：R285.5[医药卫生—中药学]