钯催化下肟醚导向的sp^2 C-H键邻位酰氧化反应(英文)  

Palladium-Catalyzed Decarboxylative ortho-Acylationof O-Methyl Ketoximesvia Direct sp^2 C-H Bond Activation

作　　者：蔡海婷[1] 李丹丹[1] 刘姿[1] 王官武[1] 

机构地区：[1]中国科学技术大学化学系合肥微尺度物质科学国家实验室,合肥230026

出　　处：《化学学报》2013年第5期717-721,共5页Acta Chimica Sinica

基　　金：Project supported by the National Natural Science Foundation of China(No.91021004);the Intercollegiate Key Project of Natural Sciences of Anhui Province,China(No.KJ2010ZD05)~~

摘　　要：使用醋酸钯作为催化剂,过硫酸钠和氧化银为氧化剂,使肟醚导向的底物与苯甲酰甲酸发生sp2C—H键的邻位酰氧化反应,从而得到芳香酮类化合物.该方法对带吸电子基和给电子基的反应物都有很好的适应性,最高产率可达98%.The palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with a-oxocarboxylic acids in the presence of NaaSEO8 and Ag20 is demonstrated. This protocol can be applied to various O-methyl ketoximes and a-oxocarboxylic acids with both electron-donating and electron-withdrawing groups with products yields up to 98%.

关 键 词：钯催化 C—H键活化 肟醚导向 脱羧 酰基化 

分 类 号：O643.32[理学—物理化学]