电针治疗慢性炎性痛的促外周beta-END释放作用  

Peripheral Beta-END Release-promoting Effects of Electroacupuncture in the Treatment of Chronic Inflammatory Pain

作　　者：何晓芬[1] 方剑乔[1] 蒋永亮[1] 黄垒[1] 裘晟晨[1] 沈亚芳[1] 尹小虎[1] 

机构地区：[1]浙江中医药大学,杭州310053

出　　处：《上海针灸杂志》2013年第5期407-409,共3页Shanghai Journal of Acupuncture and Moxibustion

基　　金：国家自然科学基金资助项目(81072855);浙江省自然科学基金资助项目(Z2100979;LY12H27015);浙江省"重中之重"学科(针灸推拿学)建设经费资助[浙教高科(2008)255号]

摘　　要：目的观察电针治疗慢性炎性痛时对炎症局部炎性介质和外周阿片肽的双重干预作用。方法建立大鼠弗氏完全佐剂(Complete Freund’s Adjuvant,CFA)诱导的慢性炎性痛模型,电针选用患侧足三里和昆仑穴,并与传统非甾体抗炎药消炎痛进行比较,观察热缩腿阈(thermal paw withdrawal latency,PWL)变化,检测足跖炎症组织前列腺素E2(PGE2)、白介素-1(IL-1)和beta-内啡肽(beta-END)。结果电针和消炎痛均可提高慢性炎性痛大鼠痛阈;电针不能显著降低炎症局部组织PGE2、IL-1水平,但能显著升高炎症局部组织beta-END水平(P<0.05);消炎痛能显著降低PGE2和IL-1水平(均P<0.01),但对beta-END水平没有显著影响。结论与传统的非甾体抗炎药相比,电针治疗慢性炎性痛具有促外周beta-END释放的作用。[Abstract] Objective To investigate the dual intervening effects of electroacupuncture on inflammatory mediators and peripheral opioid peptides in local inflammatory tissue in the treatment of chronic inflammatory pain. Methods A rat model of complete Freund＇s adjuvant （CFA）-induced chronic inflammatory pain was made. Electroacupuncture at points Zusanli and Kunlun on the affected side were compared with conventional nonsteroidal anti-inflammatory drug indomethacin. Paw withdrawal latency （PWL）, and prostaglandin E2 （PGE2）, interleukin-l[3 （IL-lJ3） and beta-endorphin （beta-END） in the plantar inflammatory tissue were measured. Results Both electroacupuncture and indomethacin raised pain threshold in the rats with chronic inflammatory pain. Electroacupuncture did not significantly reduce PGE2 and IL-1J3 levels but significantly increase beta-END levels （P〈0.05） in the local inflammatory tissue. Indomethacin significantly increased PGE2 and IL-113 levels （both P〈0.01） but did not produce a significant effect on beta-END levels. Conclusion Electroacupuncture can promote peripheral beta-END release in the treatment of chronic inflammatory pain compared with the conventional nonsteroidal anti-inflammatory drug.

关 键 词：电针 慢性炎性痛 炎性介质 阿片肽 内啡肽 大鼠 

分 类 号：R2-03[医药卫生—中医学]