TNF-α,MMP-9血清学水平与早期自然流产的相关性研究  

The correlation study on the concerntration of TNF-α,MMP-9 in serum and the early spontaneous abortion

作　　者：李雪莲[1] 初晓丽[1] 汪洋[1] 李学文[1] 张大薇[1] 戴婉波[1] 

机构地区：[1]广州医学院附属深圳沙井医院妇产科,深圳沙井518104

出　　处：《中国优生与遗传杂志》2013年第5期35-36,共2页Chinese Journal of Birth Health & Heredity

基　　金：深圳市宝安区科技局项目项目编号2008287

摘　　要：目的研究早期自然流产妇女血清中TNF-α,MMP-9的表达水平,探讨其与自然流产的关系。方法应用ELISA检测孕3月内30例自然流产及20例正常早孕妇女血清中TNF-α,MMP-9的水平。结果早期自然流产妇女血清中TNF-α,MMP-9水平明显高于正常早孕妇女,差异有统计学意义,P<0.05。结论血清中TNF-α及MMP-9水平的升高与早期自然流产有关,二者的表达异常可能促进了自然流产的发生。objective:To study the level of TNF-α,MMP-9 in serum of the early spontaneous abortion.Methods:TNF-α,MMP-9 were measured by sand wich-ELISA in 30 cases with the spontaneous abortion,20 cases of normal pregnancies as the control.Results:The serum TNF-α,MMP-9 of the early spontaneous abortion were significantly higher than those in the control group,P<0.05.Conclutions:TNF-α,MMP-9 may be associated with the oncogenesis and development of the early spontaneous abortion.The elevated expression of TNF-α and MMP-9 may be associated with oncogenesis of the early spontaneous abortion

关 键 词：自然流产 肿瘤坏死因子 基质金属蛋白酶 酶联免疫吸附测定 

分 类 号：R714.21[医药卫生—妇产科学]