含β-内酰胺酶抑制剂的复方抗生素中高聚物的研究进展  

The Research Progress of High Polymers in Antibiotics Combinations Containing β-lactamase Inhibitors

作　　者：高靓[1,2] 李苌清 薛青山[1,2] 张陆勇[4] 王霆[1,2] 

机构地区：[1]中南大学药学院,长沙410013 [2]湘北威尔曼制药股份有限公司,长沙410331 [3]重庆市红十字会医院,重庆400024 [4]中国药科大学,南京210009

出　　处：《国外医药（抗生素分册）》2013年第2期53-59,共7页World Notes on Antibiotics

基　　金：国家十二五"重大新药创制"科技重大专项2011ZX09201-101-3

摘　　要：抗生素中高聚物是导致不良反应的主要因素,对于单方抗生素中高聚物的研究已有较多的报道,相关的检测方法与控制标准也写入了药典,但对含β-内酰胺酶抑制剂的复方抗生素的高聚物研究报道较少,本文主要介绍了此类复方中高聚物的研究进展,并与单方抗生素制剂的有关研究进行了比较。High polymers, which in prescribed antibiotics have been widely researched, are the major resource of adverse reactions of antibiotics, and their quality control has been listed as a key index in pharmacopeia. But there are few reports about high polymers in antibiotics combinations containing beta-lactamase inhibitors. Here we will review advances in research of high polymers in the compound preparations and the comparison of the research between the prescribed and compound preparations will also be conducted.

关 键 词：复方抗生素 Β-内酰胺酶抑制剂 过敏反应 高聚物 分离分析方法 

分 类 号：R978.11[医药卫生—药品]