他达拉非联合行为疗法应用于男性手淫取精失败患者的临床研究  

Tadalafil combined with behavior therapy for semen collection from infertile males in whom masturbation fails

作　　者：唐文豪[1] 姜辉[1] 马潞林[1] 洪锴[1] 赵连明[1] 刘德风[1] 毛加明[1] 杨译[1] 张菊[2] 高凌[2] 乔杰[2] 

机构地区：[1]北京大学第三医院泌尿外科,北京100191 [2]北京大学第三医院生殖中心,北京100191

出　　处：《中华男科学杂志》2013年第5期439-442,共4页National Journal of Andrology

摘　　要：目的:探索他达拉非联合行为疗法辅助男性手淫取精失败患者的取精效果。方法:60例男性手淫取精失败患者随机分为他达拉非联合行为疗法组(联合治疗组)和单用他达拉非组(对照组),每组30例。两组患者均手淫取精前1晚口服他达拉非20 mg。联合治疗中行为疗法是在家中练习手淫取精16～24次后再手淫取精。结果:联合治疗组和对照组患者年龄分别为(37.0±5.1)岁和(37.5±5.2)岁;IIEF-5评分分别为(16.50±1.25)分和(16.90±1.09)分,两组之间年龄和IIEF-5评分均无统计学差异(P>0.05)。联合治疗组9例取精成功,成功率为30.0%(9/30);对照组1例取精成功,成功率为3.33%(1/30)。χ2检验显示,两组之间存在显著的统计学差异(χ2=7.680,P<0.01)。结论:联合治疗组经过行为疗法(手淫取精)训练和学习过程,建立手淫取精的条件反射,对成功取精起到了有利的促进作用,较单独应用他达拉非组明显提高了取精成功率,因此联合治疗更有助于男性手淫取精失败患者成功取精。Objective： To study the effect of Tadalafil combined with behavior therapy in helping obtain semen from infertile men in whom masturbation has failed. Methods ： Sixty male infertile patients from whom masturbation had failed to obtain semen were equally assigned to receive Tadalafil combined with behavior therapy （ combination group） or Tadalafil only （ control group）. All the patients took Tadalafil 20 mg orally the night before the day of semen collection by masturbation. Before this procedure, the patients of the combination group practiced masturbation 16 - 24 times at home. Results： The average ages of the patients were （ 37.0 ± 5.1 ） yr and （37.5 ±5.2） yr and their IIEF-5 scores were 16.50 ± 1.25 and 16.90 ± 1.09 in the combination and the control group, respectively, neither with statistically significant difference between the two groups. Semen was successfully obtained from 9 patients （30.0%） of the combination group and 1 patient （3.33%） of the control group, with statistically significant difference between the two groups （ χ2 = 7. 680, P 〈 0.01 ）. Conclusion ： By training the patients and establishing a conditioned response to masturbation, Tadalafil combined with behavior therapy can significantly increase the success rate of semen collection from the male infertile patients in whom masturbation fails.

关 键 词：他达拉非 行为疗法 取精失败 

分 类 号：R698.2[医药卫生—泌尿科学]