腰背痛患者静息态fMRI的脑功能局部一致性研究  

Regional homogeneity alterations in subjects with low back pain disorders： a resting-state fMRI study

作　　者：张珊珊[1] 吴文[1] 刘自平[1] 郭世贵[1] 杨建明[2] 

机构地区：[1]南方医科大学珠江医院康复医学科,广州510282 [2]南方医科大学珠江医院影像诊断科,广州510282

出　　处：《中华神经医学杂志》2013年第5期506-510,共5页Chinese Journal of Neuromedicine

基　　金：广东省科技计划项目（20078031402007）

摘　　要：目的利用功能磁共振成像（fMRI）技术探讨静息状态下腰背痛患者脑局部一致性（ReHo）变化的特点。方法选择自2011年8月至2012年1月南方医科大学珠江医院康复医学科招募的15例年龄、性别和文化程度相近的健康者作为受试者，向其右侧腰背部肌肉注射0．3mL30以的高渗盐水制造腰背痛模型，采用3．0TMR仪分别在注射前、注射后进行静息状态fMRI扫描，所得数据进行配对t检验，比较疼痛及非疼痛状态下静息态脑功能的局部一致性差异。结果与正常状态相比，腰背痛受试者ReHo增高的脑区有：双侧前额叶内侧、左额下回、右额中回、右小脑扁桃体、右脑桥、右岛叶、右尾状核、右楔前叶、右海马旁回、后扣带回；ReHo减低的脑区有：右颞上回、左颞中回、左中央前回、左中央后回、左海马旁回、左梭状回、左前扣带回、左顶上小叶、右顶下小叶（P〈0．005，体素值≥10）。结论静息状态下腰背痛患者部分脑区存在脑活动区域一致性异常。Objective To explore the characteristics of the brain regional homogeneity （ReHo） alterations in patients with low back pain disorders using resting-state functianal magnetic resonance imaging （fMRI）. Methods Resting-sate fMRI 3.0T scans were separately performed on 15 age- and gender-matched healthy subjects at rest as baseline and during pain of the back muscle （intramuscular injection of 3 g/L hypertonic saline）. The ReHo maps were analyzed with paired t-test to compare the changes between the pain and healthy status. Results As compared with the health subjects, the subjects with low back pain showed significantly increased ReHo levels in the bilateral medial prefrontal cortex （mPFC）, left inferior frontal gyrus, right middle frontal gyrus, cerebellum posterior lobe-cerebellar tonsil, right ports, right insula, right caudate, right precuneus, right parahippocampa gyrus and posterior cingnlate gyrus, and decreased ReHo levels in the right superior temporal gyrus, left middle temporal gyrus, left precentral gyrus, left postcentral gyrus, left parahippocampa gyrus, left fusiform gyrus, left anterior cingulate, left superior parietal lobule, right inferior parietal lobule （P〈0.005, cluster threshold ≥ 10）. Consulsion People with low back pain show abnormal spontaneous activity in certain brain regions.

关 键 词：疼痛 静息态 功能性磁共振成像 局部一致性 

分 类 号：R445.2[医药卫生—影像医学与核医学]