APOBEC3G基因多态性与慢性乙型肝炎易感性的关系  

Association between APOBEC3G polymorphisms and susceptibility to chronic hepatitis B

作　　者：游志毅[1] 周福元[2] 王雄虎[1] 陈楚明[2] 周军华[3] 赵德坚[3] 胡贵方[3] 

机构地区：[1]南方医科大学公共卫生与热带医学学院流行病学系,广东广州510515 [2]南方医科大学南方医院感染内科,广东广州510515 [3]南方医科大学 公共卫生与热带医学学院流行病学系,广东广州510515

出　　处：《南方医科大学学报》2013年第5期769-771,共3页Journal of Southern Medical University

基　　金：“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项“十一五”课题(2009ZX1001-081)

摘　　要：目的探讨载脂蛋白B mRNA编辑酶催化多肽3G(APOBEC3G)基因rs185983011位点在人群中的多态性分布,并研究其与慢性乙型肝炎易感性的关系。方法分别收集186例HBsAg和HBeAg皆阴性的健康者、159例慢性乙型肝炎患者的血液样本。应用Sanger测序方法检测该研究对象APOBEC3G基因rs185983011位点的多态性,确定其基因型及等位基因分布情况。并将该位点的多态性与慢性乙型肝炎的易感性之间的关系进行统计学分析。结果 SNP rs1 8598301 1位点存在于检测人群中的基因型只有C/C和C/T,其中以C/C为主(97.7%)。SNP rs185983011位点的基因型频率和等位基因频率在慢性乙型肝炎患者组和健康者组中的分布无统计学差异(P>0.05)。结论研究人群APOBEC3G基因中rs185983011位点的基因型主要是C/C,未发现该位点的多态性与慢性乙型肝炎易感性存在相关性。Objective To investigate the association between rs185983011 single-nucleotide polymorphisms （SNP） of apolipoprotein B mRNA editing enzyme catalyitc polypeptide-like 3G （APOBEC3G） and the susceptibility to chronic hepatitis B. Methods The blood samples were collected from 186 healthy subjects and 159 patients with chronic hepatitis B. The rs185983011 SNP was detected and genotyped by sequencing with Sanger＇s method to analyze the relationship between rs185983011 SNP and chronic hepatitis B. Results Only C/C and C/T genotypes of the alleles of rs185983011 SNP were found in the tested subjects, and the C/C genotype was predominant （97.7%）. The distribution frequencies of rs185983011 SNP genotypes and alleles showed no significant difference between healthy subjects and patients with chronic hepatitis B （P〉0.05）. Conclusion The predominant genotype of rs185983011 SNP of APOBEC3G is C/C in the tested subjects, and rs185983011 SNP does not appear to associate with the susceptibility to chronic hepatitis B.

关 键 词：多态性分布 载脂蛋白B mRNA编辑酶催化多肽3G 慢性乙型肝炎 单核苷酸多态性 

分 类 号：R512.62[医药卫生—内科学]