乳癌组织LRP16、Ki67及EGFR表达及其与预后关系  

EXPRESSIONS OF LRP16,Ki67,AND EGFR IN BREAST CANCER AND THEIR CORRELATION WITH THE PROGNOSIS OF THE DISEASE

作　　者：李振凤[1] 宋修岐[2] 邹晓[1] 石晶晶[1] 

机构地区：[1]青岛大学医学院第二附属医院乳腺科,山东青岛266042 [2]青岛大学医学院第二附属医院普外科,山东青岛266042

出　　处：《齐鲁医学杂志》2013年第2期124-126,共3页Medical Journal of Qilu

摘　　要：目的探讨白血病相关性基因(LRP16)、增殖细胞核抗原(Ki67)及表皮生长因子受体(EGFR)表达与乳癌临床病理因素及预后的关系。方法应用免疫组化S-P二步法检测60例乳癌手术切除标本中LRP16、Ki67及EGFR的表达,并统计分析上述指标与乳癌临床病理因素及预后的关系。结果 LRP16、Ki67及EGFR在乳癌组织中的阳性表达率分别为53.3%、71.7%与10.0%;LRP16表达与肿瘤大小、脉管癌栓、淋巴结转移、组织分级、临床分期及雌激素受体(ER)状态有关(χ2=5.238～14.464,P<0.05);Ki67表达与肿瘤大小、淋巴结转移、组织分级、临床分期有关(χ2=4.938～16.972,P<0.05);EGFR表达与组织分级、ER状态、孕激素受体状态有关(χ2=4.762～10.000,P<0.05);LRP16与Ki67、ER表达呈显著正相关(r=0.450、0.361,P<0.01);LRP16及Ki67表达与术后复发转移呈显著负相关(r=-0.317、-0.279,P<0.05)。结论联合检测乳癌组织中LPR16、Ki67、EGFR的表达可为乳癌的诊断、个体化治疗方案选择及预后评估提供参考依据。Objective To investigate the relationship between the expression of leukemia-related protein 16(LRP16),nuclear-associated antigen Ki-67(Ki67),and epidermal growth factor receptor(EGFR) in breast carcinoma and clinicopathologic factors and prognosis.Methods Immunohistochemical S-P method was utilized to detect the expressions of LRP16,Ki67 and EGFR in 60 cases of breast carcinoma.The relationship between the above parameters and clinicopathologic factors and prognosis was analyzed statistically.Results Positive rates of LRP16,Ki67 and EGFR in breast cancer were 53.3%,71.7% and 10.0%,respectively.LRP16 was correlated with tumor size,vessel cancer embolus,lymph node metastasis,grade,clinical stage and estrogen receptor(ER)(χ2=5.238-14.464,P<0.05);Ki67 was correlated with tumor size,lymph node metastasis,grade,and stage(χ2=4.938-16.972,P<0.05);EGFR was correlated with grade,ER and progesterone receptor(PR)(χ2=4.762-10.000,P<0.05);LRP16 was positively correlated with Ki67 and ER(r=0.450,0.361;P<0.01),both LRP16 and Ki67 negatively correlated with postoperative recurrence and metastasis(r=-0.317,-0.279;P<0.05).Conclusion Joint detection of LRP16,Ki67 and EGFR expression in breast cancer tissue can provide a reference for selecting individualized treatment and asses-sing the prognosis of this malignancy.

关 键 词：乳腺肿瘤 白血病相关性基因 增殖细胞核抗原 受体 表皮生长因子 预后 

分 类 号：R655[医药卫生—外科学]