贝那普利联合胺碘酮对慢-快综合征患者DDD起搏器植入术后阵发性心房颤动的干预作用  

Effects of Benazepril and Amiodarone on Paroxysmal Atrial Fibrillation in Patients with Slow-fast Syndrome after DDD Pacing

作　　者：王兵[1] 江洪[2] 陈玲[3] 丁峰[3] 董艳芬[3] 孙玉玲[3] 

机构地区：[1]武汉大学基础医学院,武汉430072 [2]武汉大学人民医院心内科,武汉430060 [3]安徽省砀山县人民医院心内科,安徽砀山235300

出　　处：《医学综述》2013年第9期1682-1684,共3页Medical Recapitulate

摘　　要：目的观察贝那普利联合胺碘酮对慢-快综合征患者DDD起搏器植入术后阵发性心房颤动(简称房颤)的干预作用。方法将2007年1月至2011年1月由武汉人民医院收治的22例慢-快综合征DDD起搏器植入术后合并阵发性房颤的患者随机分成治疗组和对照组,治疗组采用贝那普利联合胺碘酮进行治疗,对照组采用胺碘酮进行治疗,随访18个月,比较两组治疗后左心房内径及窦性心律的维持率。结果治疗9个月,两组左心房内径及窦性心律的维持率进行比较,差异均无统计学意义(P>0.05);治疗18个月,治疗组左心房内径较对照组明显缩小,治疗组窦性节律维持率亦明显高于对照组(P<0.05);治疗组治疗后18个月,左心房内径较治疗前亦明显缩小(P<0.05)。结论贝那普利联合胺碘酮治疗的确能降低慢-快综合征患者DDD起搏器植入术后阵发性房颤的发生率和复发率,增加窦性节律的维持率,且能抑制左心房进一步扩大。Objective To investigate the effects of benazepril and amiodarone on paroxysmal atrial fibri llation（ AF for short）in patients with slow-fast syndrome after DDD pacing. Methods 22 cases with slow- fast syndrome after DDD pacing complicated with paroxysmal atrial fibrillation admitted by People＇s Hospital of Wuhan University from Jan. 2007 to Jan. 2011 were divided into 2 groups, observation group and control group. Benazepril and amiodarone were administrated to patients in observation group, while amiodarone to patients in control group ,the treatment lasted for 18 months in both groups ,and then the inner diameter of the left atrium and sinus rhythm maintenance rate of the 2 groups were compared. Results After 9 months, the maintenance rate of sinus rhythm and left atrial diameter between the 2 groups were not statistically significantly different （ P 〉 0.05 ）. After 18 months of treatment, the left atrial diameter of the observation group was significanlly reduced than the control group, and the sinus rhythm maintenance rate of the observation group was significantly higher than the control group （ P 〈 0.05 ） ; after 18 months of treatment the left atrial diameter of the observation group was significantly reduced than before the treatment （ P 〈 0.05 ）. Conclusion Benazepril combined with amiodarone can obviously decrease the incidence and recurrence of paroxysmal atrial fibrillation in patients with slow-fast syndrome after DDD pacemaker implantation, significantly increase the rate of sinus rhythm maintenance,and inhibit the further expansion of the left atrium.

关 键 词：心血管病学 慢-快综合征 阵发性心房颤动 DDD起搏器 胺碘酮 电-解剖重构 

分 类 号：R972.2[医药卫生—药品] R318.11[医药卫生—药学]