急性冠脉综合征患者血浆IL-6、MMP水平及瑞舒伐他汀的干预作用  

Levels of plasma inflammatory mediators of acute coronary syndrome and intervention effect of rosuvastatin

作　　者：赵秀峰[1] 刘丽军[1] 信栓力[1] 常超[1] 张兰华[1] 刘桂兰[1] 裴利敏[1] 李琴[1] 马燕霞[1] 朱洁莹[1] 

机构地区：[1]邯郸市第一医院心内科,邯郸056002

出　　处：《中国循证心血管医学杂志》2013年第2期134-135,共2页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：河北省医学科学研究重点课题计划(07150)

摘　　要：目的探讨急性冠脉综合征(ACS)患者体内血浆白细胞介素-6(IL-6)及基质金属蛋白酶-9(MMP-9)的变化以及瑞舒伐他汀对二者的干预作用。方法纳入2011年3月～2011年11月邯郸市第一医院行冠脉造影确诊ACS患者55例(ACS组),同期纳入胸痛行冠脉造影但结果正常者30例(对照组),采用酶联免疫吸附法(ELISA)检测所有受试者IL-6和MMP-9水平,比较两组差异;ACS组患者口服瑞舒伐他汀(10mg/d)4周后再次检测IL-6和MMP-9血浆水平,比较治疗前、后的差异。结果与对照组相比,ACS组IL-6和MMP-9水平均较高[分别为:(23.76±5.78)ng/mlvs.(17.56±5.34)ng/ml和(19.87±5.68)mg/Lvs.(16.59±5.13)mg/L],差异有统计学意义(P<0.01),ACS组患者服用瑞舒伐他汀4周后血浆IL-6和MMP-9水平明显下降(P<0.05)。结论炎症反应可能参与ACS的发病过程,瑞舒伐他汀具有抑制炎症反应的作用。Objective To investigate the level changes of plasm interleukin-6 （IL-6） and metalloproteinase-9 （ MMP-9 ） and intervention effect of rosuvastatin in patients with acute coronary syndrome （ ACS ） . Methods The patients with ACS diagnosed by coronary angiography （ CAG, n=55, ACS group ） and patients with chest pain and normal CAG outcomes （ n=30, control group ） were chosen from Mar. 2011 to Nov. 201 l. The levels of IL-6 and MMP-9 were detected by using enzyme-linked immunosorbent assay （ ELISA ） and compared between two groups. ACS group was orally given rosuvastatin （ 10 mg/d ） for 4 weeks, and then the levels of 1L-6 and MMP-9 were detected again and compared before and after treatment. Results Compared with control group, the levels of IL-6 and MMP-9 were higher in ACS group [ （ 23.76 ± 5.78 ） ng/ml vs. （ 17.56 ± 5.34 ） ng/ml and （ 19.87 ± 5.68 ） mg/L vs. （ 16.59 ± 5.13 ） mg/L, P〈0.01]. After taking rosuvastatin for 4 weeks, the levels of IL-6 and MMP-9 decreased significantly in ACS group （ P〈0.05 ） . Conclusion Inflammatory response may take part in the pathogenesis of ACS, and rosuvastatin has the effect of inhibiting inflammatory response.

关 键 词：瑞舒伐他汀 急性冠脉综合征 白细胞介素-6 基质金属蛋白酶-9 

分 类 号：R541.4[医药卫生—心血管疾病]