多杀霉素-壳聚糖共聚物微球的制备及性能评价  

Preparation and Characteristics Analysis of Microsphere of Spinosad-chitosan Copolymer

作　　者：徐蕾 曹立冬[2] 李凤敏[2] 王相晶[1] 黄啟良[2] 

机构地区：[1]东北农业大学生命科学学院,黑龙江哈尔滨150030 [2]中国农业科学院植物保护研究所,北京100193

出　　处：《农药科学与管理》2013年第5期23-26,共4页Pesticide Science and Administration

基　　金：自然科学基金(30971947);中央级公益性科研院所基本科研业务费(1610142012014)

摘　　要：以壳聚糖和DL-丙交酯为原料合成新型载体材料CS-co-PLA,通过纳米沉淀法制备多杀霉素载药粒子。利用高效液相色谱研究不同聚合物和药物质量比对载药量和包载率的影响以及载药粒子在不同环境条件下的控制释放性能。实验结果表明:多杀霉素载药粒子粒径分布均匀,具有良好的缓释性能。In this paper, chitosan-lactide polymer （CS-co-L＇LA） was prepareu as splnosau carrier by nano-precipitation method. The influence of feed mass ratio of copolymer to spinosad on the loading content and encapsulation efficiency was investigated. Furthermore, the sustained release characteristics of spinosad-incapsulated particles under different environmental conditions were explored. The results show that the spinosad-incapsulated particles were featured uniform size distribution and exhibited sustained release performance.

关 键 词：壳聚糖 多杀霉素 载药粒子 缓释 

分 类 号：TQ453[化学工程—农药化工]