灯盏花乙素和双嘧达莫舒张离体大鼠心脑血管的药理作用  

Vasodilative Effects of Two Natural Products on Isolated Rat Coronary and Basilar Arteries

作　　者：胡娜[1] 王蕾[2] 陈亚娟[1] 王友兰 杨为民[1] 

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650031 [2]昆明医科大学基础医学院药理学系,云南昆明650031 [3]昆明市医学科学研究所,云南昆明650011

出　　处：《昆明医科大学学报》2013年第3期4-7,21,共5页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(30960450;8117311);云南省科技厅应用基础重点项目(2011FA022);云南省重点新产品开发计划项目(2012BC012)

摘　　要：目的研究灯盏花乙素(scutellarin,SCU)、双嘧达莫对正常大鼠冠状动脉(coronary artery,CA)和脑基底动脉(basilar artery,BA)的影响.方法选择正常SD大鼠,制备冠状动脉环和脑基底动脉环,应用Myograph血管张力分析系统测定血管环的张力变化,累积剂量法加入受试药物,观察受试药物对血栓素受体激动剂U46 619所致血管收缩作用的影响.结果与溶媒对照血管相比,SCU和双嘧达莫能明显舒张U46619预收缩的冠状动脉(P<0.05);与溶媒对照血管相比,2种药皆能明显舒张U46619预收缩的脑基底动脉(P<0.001).结论 SCU、双嘧达莫对脑基底动脉和冠状动脉具有一定的舒张作用.Objective To investigate the effects of scutellarin（SCU） and dipyridamole on the isolated rat coronary artery（CA） and basilar artery（BA） rings.Methods Isolated rat CA and BA rings from SD rats were prepared,and then tension changes were measured by Myograph system.Effects of tested drugs on artery rings pretreated by thromboxane receptor agonist U46619 were determined.Results Compared with solvent group,SCU and dipyridamole exhibited significant vasodilating activity against U46619-induced contraction in CA rings（P 0.05） and BA rings（P 0.001）.Conclusions SCU and dipyridamole were shown to possess vasodilative effects on isolated rat CA and BA.

关 键 词：灯盏花乙素 双嘧达莫 大鼠离体血管环 

分 类 号：R542.22[医药卫生—心血管疾病] R-332[医药卫生—内科学]