Autophagy modulation as a target for anticancer drug discovery  

作　　者：Xin LI Huai-long XU Yong-xi LIU Na AN Si ZHAO Jin-ku BAO 

机构地区：[1]School of Life Sciences & State Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu610064, China

出　　处：《Acta Pharmacologica Sinica》2013年第5期612-624,共13页中国药理学报（英文版）

基　　金：Acknowledgements We are grateful to Lei WU, Zi-jie WANG, and Rong SUN for their critical review of this manuscript. This work was sup- ported by the National Natural Science Foundation of China （No 30970643, No 81173093 and No J1103518） and Special Pro- gram for Youth Science and Technology Innovative Research Group of Sichuan Province, China （No 2011JTD0026）.

摘　　要：an evolutionarily conserved catabolic process involving the engulfment and degradation of non-essential or abnormal cel- lular organelles and proteins, is crucial for homeostatic maintenance in living cells. This highly regulated, multi-step process has been implicated in diverse diseases including cancer. Autophagy can function as either a promoter or a suppressor of cancer, which makes it a promising and challenging therapeutic target. Herein, we overview the regulatory mechanisms and dual roles of autophagy in cancer. We also describe some of the representative agents that exert their anticancer effects by regulating autophagy. Additionally, some emerging strategies aimed at modulating autophagy are discussed as having the potential for future anticancer drug discovery. In summary, these findings will provide valuable information to better utilize autophagy in the future development of anticancer thera- peutics that meet clinical requirements.an evolutionarily conserved catabolic process involving the engulfment and degradation of non-essential or abnormal cel- lular organelles and proteins, is crucial for homeostatic maintenance in living cells. This highly regulated, multi-step process has been implicated in diverse diseases including cancer. Autophagy can function as either a promoter or a suppressor of cancer, which makes it a promising and challenging therapeutic target. Herein, we overview the regulatory mechanisms and dual roles of autophagy in cancer. We also describe some of the representative agents that exert their anticancer effects by regulating autophagy. Additionally, some emerging strategies aimed at modulating autophagy are discussed as having the potential for future anticancer drug discovery. In summary, these findings will provide valuable information to better utilize autophagy in the future development of anticancer thera- peutics that meet clinical requirements.

关 键 词：autoDhagy： cancer： aDODtOSiS： anti-cancer drug： microRNA 

分 类 号：Q523[生物学—生物化学] S896.6[农业科学—特种经济动物饲养]