早期血乳酸清除率对AECOPD并呼吸衰竭患者预后评估的意义  

The prognostic evaluation significance of early blood lactate clearance rate for AECOPD with respiratory failure patients

作　　者：茹晃耀[1] 劳志刚[1] 戴良成[1] 王素宁[1] 吴昊[1] 宋斐[1] 

机构地区：[1]广东药学院附属第一医院重症医学科,广东广州510080

出　　处：《中国医药科学》2013年第9期70-71,共2页China Medicine And Pharmacy

摘　　要：目的探讨早期乳酸清除率对评估急性加重期慢性阻塞性肺疾病（AECOPD）并呼吸衰竭患者预后的价值。方法收集我院重症医学科2011年9月～2012年12月64例AECOPD并呼吸衰竭患者64例，按照28d预后分为生存组和死亡组。记录确诊后初始动脉血乳酸、6h乳酸清除率、24h内急性生理与慢性健康状况（APACHEⅡ）评分及患者的转归。以6h血乳酸清除率大于等于10％为界分为高乳酸清除率组和低乳酸清除率组，比较其差异性。结果各组间年龄、性别构成、初始动脉血乳酸差异无统计学意义（P〉O．05），生存组6h乳酸清除率明显高于死亡组，低乳酸清除率组病死率明显高于高乳酸清除率组，差异均有统计学意义（P〈0．05）。结论早期血乳酸清除率对AECOPD并呼吸衰竭患者预后判定具有一定价值。Objective To investigate the prognostic evaluation value of early blood lactate clearance rate for acute exacerbation of chronic obstructive pulmonary disease（AECOPD） with respiratory failure patients. Methods 64 AECOPD patients cured in intensive care unit since September,2011 to December 2012 were retrospective analyzed,and they were divided into survival group and death group according the 28 days prognosis. Blood lactate level after diagnosis,6 h lactate clearance rate,24 h acute physiology and chronic health evaluationII （APACHE U ）,and the outcomes were statistics analyzed. Besides,the 64 patients were divided into another two groups：high lactate clearance rate group which greater than or equal to 10%,and the low lactate clearance rate group which less than 10%,the mortality was also statistics analyzed. Results The average age,sexual distinction,and the blood lactate level after diagnosis were no significant between both two groups（P 〉 0.05）;while 6 h lactate clearance rate of survival group was higher than death group. And the mortality of low lactate clearance rate group was higher than high lactate clearance rate. They were statistically significant（P 〈 0.05）. Conclusion Early blood lactate clearance rate can help to judge the prognostic of the AECOPD with respiratory failure patients.

关 键 词：AECOPD 早期血乳酸清除率 APACHEⅡ 

分 类 号：R563[医药卫生—呼吸系统]