五味子藤化学成分研究  

Chemical constituents of Schisandra chinensis

作　　者：叶丹丹[1] 梁会娟[2] 袁永亮[3] 李婷[1] 白素平[1] 

机构地区：[1]新乡医学院药学院,河南新乡453003 [2]新乡医学院第三附属医院药剂科,河南新乡453003 [3]中国药科大学药学院,江苏南京210009

出　　处：《新乡医学院学报》2013年第5期329-331,336,共4页Journal of Xinxiang Medical University

基　　金：国家自然科学基金资助项目(编号:81072552);河南省科技创新杰出青年基金资助项目(编号:104100510016)

摘　　要：目的研究五味子藤茎的化学成分,为进一步研究其生物活性提供依据。方法利用硅胶柱层析进行分离和纯化化合物,用波谱分析方法鉴定其结构。结果从五味子藤茎中分离得到5个化合物,其中3个倍半萜:6β,8β-二羟基艾里莫芬-7(11)-烯-12,8α-内酯(1)、6β,8α-二羟基里艾莫芬-7(11)-烯-12,8β-内酯(2)、Bullatantriol(3);1个异黄酮:大豆素(4);1个有机酸:反式肉桂酸(5)。结论化合物1和2为首次从五味子属植物中分离得到。Objective To study the chemical composition of Schisandra chinensis and provide guidance for further in- vestigation of its bioactivity. Methods Compounds were separated and purified by silica gel column chromatography and their structures were determined by spectroscopic methods. Results Five compounds were isolated and identified from Schisandra chinensis. Three of them were sesquiterpenoids 6β,8 βdihydroxyeremophil-7 （ 11 ） -en-12,8a-olide （ 1 ）, 6β,8a-dihydroxyere- mophil-7 （ 11 ） -en-12,8β-olide （ 2 ） , Bullatantriol （ 3 ） ; one was isoflavonoid Daidzein （4） , and the other one was trans-Cinnamie acid（5）. Conclusion Compounds 1 and 2 were separated from Schisandra chinensis for the first time.

关 键 词：五味子 化学成分 倍半萜 

分 类 号：R284.1[医药卫生—中药学]