3种方法在慢性荨麻疹治疗中的临床疗效观察  

Clinical efficacy of three methods in treatment of chronic urticaria

作　　者：郭文丽 李克寒[2] 贾新安[2] 赵春华 

机构地区：[1]洛阳市第六人民医院皮肤科,河南洛阳471003 [2]河南科技大学第一附属医院麻醉科,河南洛阳471003

出　　处：《新乡医学院学报》2013年第5期390-392,共3页Journal of Xinxiang Medical University

摘　　要：目的评价3种方法在慢性荨麻疹治疗中的临床效果。方法选择114例慢性荨麻疹患者随机分为对照组、观察1组和观察2组,每组38例;对照组患者每晚口服依巴斯汀10mg,观察1组患者每晚口服地氯雷他定5mg及依巴斯汀10mg,观察2组患者每晚口服依巴斯汀10mg、多赛平25 mg,另口服桂利嗪25mg,每日3次;疗程4周。治疗结束后对各组的症状积分进行记录并评价疗效。停药4周后对各组患者的复发情况进行随访。结果 3组患者治疗后症状积分显著低于治疗前,差异有统计学意义(P<0.01)。治疗后观察1组和观察2组患者的症状积分显著低于对照组,差异有统计学意义(P<0.01)。观察1组和观察2组患者的显效率(84.21%和89.47%)显著高于对照组(63.16%),差异有统计学意义(P<0.01)。停药4周后观察1组和观察2组患者的复发率(23.68%和21.05%)显著低于对照组(52.63%),差异有统计学意义(P<0.01)。观察1组和观察2组患者的显效率和复发率比较差异无统计学意义(P>0.05)。结论依巴斯汀联合地氯雷他定、依巴斯汀联合桂利嗪及多赛平治疗慢性荨麻疹患者临床效果较单用依巴斯汀效果好,不良反应少,且停药后复发率较低。Objective To evaluate the clinical efficacy of three methods in the treatment of chronic urticaria were di- vided into control group, observation group one and observation group two randomly,38 cases in each group. Methods One hundred and fourteen cases of chronic urticaria were divided into control group, observation group one and observation group two randomly ,38 cases in each group. Patients in control group were given oral ebastine l0 mg per night;patients in observation group one were given oral loratadine 5 mg and ebastine 10 mg per night;patients in observation group two were given oral ebas- fine lO mg and doxepin 25 mg per night ,combined with cinnarizine 25 mg,3 times a day. Treatment course was 4 weeks. Symp- tom scores of the three groups were recorded and the efficacy were evaluated. Recurrence of the patients in the three groups were followed up. Results Symptom scores of the three groups after treatment were lower than those before treatment signifi- cantly（ P 〈 0. 01 ）. After treatment, symptom scores of observation group one and observation group two were lower than those in control group significantly（P 〈 0.01 ）;excellence rate of observation group one and observation group two（84. 21% and 89.47% ） were higher than those in control group（63.16% ） （ P 〈0. 01 ）. Recurrence rates after four weeks drug withdrawal of observation group one and observation group two（23.68% and 21.05% ） were lower than those in control group significantly （52.63%） （P 〈 0.01 ）. There was no significant difference in excellence rate and recurrence rate between observation group one and observation group two（ P 〉 0.05 ）. Conclusion The clinical efficacy of ebastine combined with loratadine and ebas- tine combined with cinnarizine and doxepin were better than single ebastine for the low adverse reactions and low recurrence rate.

关 键 词：慢性荨麻疹 依巴斯汀 地氯雷他定 症状积分 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]