O-羧甲基壳聚糖的吸湿、保湿性研究  

Study on Hydroscopicity and Moisture Retention of O-carboxymethyl Chitosan

作　　者：吴迪[1,2] 刘桂萍 刘辉[1] 张婧[1,2] 邹萍[1,2] 

机构地区：[1]广州军区武汉总医院药剂科,武汉430070 [2]湖北中医药大学药学院 [3]湖北省荆州市肿瘤医院

出　　处：《中国药师》2013年第5期639-641,共3页China Pharmacist

基　　金：全军医学科研"十二五"计划课题(编号:CWS11C274);武汉市科技攻关计划(编号:200960323135)

摘　　要：目的:考察自制O-羧甲基壳聚糖的吸湿,保湿性能。方法:以甘油,山梨醇为对照,采用称量法测定样品的吸湿率和水分残存率,研究自制O-羧甲基壳聚糖(O-CMC)的吸湿性和保湿性能,并与N,O-羧甲基壳聚糖(N,O-CMC),水溶性壳聚糖(CTS),壳聚糖盐酸盐(CTS·HCl)等壳聚糖及其他羧甲基壳聚糖衍生物进行比较。结果:48 h后O-CMC,N,O-CMC,CTS,CTS·HCl及甘油,山梨醇在相对湿度(RH)43%条件下的吸湿率分别为9%,11.7%,8.7%,6.78%,3.2%和1.1%;在RH82%条件下的吸湿率分别为42.2%,40.6%,35.32%,31.4%,24.4%和1.2%;在相对湿度RH43%条件下的水分残存率分别为159%,126%,124%,107%,93%和13%;在干硅胶条件下的水分残存率分别为68%,84%,66%,60%,27%和11%。结论:O-CMC的吸湿性和保湿性能均优于壳聚糖及其他羧甲基壳聚糖衍生物,具有良好的吸湿,保湿性。Objective：To investigate the hydroscopicity and moisture retention of self-made O-carboxymethyl chitosan（O-CMC）. Method：Using glycerol and sorbitol as the control samples,the hydroscopicity and moisture retention of O-CMC were investigated by weighing method compared with chitosan and such chitosan derivatives as N,O-carboxymethyl chitosan（N,O-CMC）,water soluble chitosan（CTS） and chitosan hydrocholide（CTS·HC1）.Result;After 48h,the rate of moisture absorption of O-CMC,N,O-CMC, CTS,CTS·HC1,glycerol and sorbitol was 9%,11.7%,8.7%,6.78%,3.2%and 1.1%,respectively under RH of 43%,and 42.2%,40.6%,35.32%,31.4%,24.4%and 1.2%,respectively under RH of 82%.The water residual rate was 159%,126%, 124%,107%,93%and 13%,respectively under RH of 43%,and 68%,84%,66%,60%,27%and 11%,respectively with dry silica gel.Conclusion;Both the hydroscopicity and moisture retention of O-CMC are better than those of chitosan and its derivatives.

关 键 词：O-羧甲基壳聚糖 壳聚糖 壳聚糖衍生物 吸湿性 保湿性 

分 类 号：TQ460.4[化学工程—制药化工]