A total synthesis of mycalisine A  

作　　者：Yan-Hui Dou Hai-Xin Ding Ru-Chun Yang Wei Li Qiang Xiao 

机构地区：[1]Jiangxi Key Laboratory of Organic Chemistry,Jiangxi Science & Technology Normal University

出　　处：《Chinese Chemical Letters》2013年第5期379-382,共4页中国化学快报（英文版）

基　　金：NSFC(Nos.20962009 and 21062006);NCET(No.11- 1000);the Training Project of Jiangxi Youth Scientists,Education Department of Jiangxi Province(Nos.GJJ1 1223 and GJJ12583);Bureau of Science & Technology of Nanchang City for financial support

摘　　要：In this paper,we report a total synthesis of a naturally occurring pyrrolo[2,3-d]pyrimidine nucleoside, mycalisine A.Our synthetic strategy uses D-xylose as the starting material and Vorbr（u｜¨）ggen glycosylation as the key step.Mycalisine A was synthesized in 11 steps with a 15%overall yield.In this paper,we report a total synthesis of a naturally occurring pyrrolo[2,3-d]pyrimidine nucleoside, mycalisine A.Our synthetic strategy uses D-xylose as the starting material and Vorbr（u｜¨）ggen glycosylation as the key step.Mycalisine A was synthesized in 11 steps with a 15%overall yield.

关 键 词：Naturally occurring nucleoside Total synthesis Vorbruiggen glycosylation Miycalisines A Pyrrolo[2 3-d]pyrimidine 

分 类 号：O621.3[理学—有机化学]