Synthesis of novel copolymer:Poly(p-dioxanone-co-L-phenylalanine)  

作　　者：Bing Wang Chi Ma Zuo-Chun Xiong Cheng-Dong Xiong Quan-Hua Zhou Dong-Liang Chen 

机构地区：[1]Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences [2]University of Chinese Academy of Sciences [3]Sichuan Staff University of Science and Technology

出　　处：《Chinese Chemical Letters》2013年第5期392-396,共5页中国化学快报（英文版）

基　　金：supported financially by the "Western Light" joint researcher program of Chinese Academy of Science

摘　　要：In order to expand the application of poly（p-dioxanone） or PPDO in biomedical area,a series of novel copolymers were synthesized successfully by one-step,melted copolymerization of p-dioxanone（PDO） and L-phenylalanine N-carboxyanhydride（L-Phe-NCA） monomers.With the in-feed molar ratio of L-PheNCA /PDO equal to 1/20,the conversions of the two kinds of monomers were calculated from 1H NMR. The average molecular weight and polydispersity of the copolymer increase with the increasing reaction time and catalyst concentration.However,the conversions of the two kinds of monomers did not change with the reaction conditions.A three-step mechanism is presented and proved by high resolution 1H NMR and IR spectrums.In order to expand the application of poly（p-dioxanone） or PPDO in biomedical area,a series of novel copolymers were synthesized successfully by one-step,melted copolymerization of p-dioxanone（PDO） and L-phenylalanine N-carboxyanhydride（L-Phe-NCA） monomers.With the in-feed molar ratio of L-PheNCA /PDO equal to 1/20,the conversions of the two kinds of monomers were calculated from 1H NMR. The average molecular weight and polydispersity of the copolymer increase with the increasing reaction time and catalyst concentration.However,the conversions of the two kinds of monomers did not change with the reaction conditions.A three-step mechanism is presented and proved by high resolution 1H NMR and IR spectrums.

关 键 词：COPOLYMER P-DIOXANONE L-PHENYLALANINE MECHANISM 

分 类 号：O631.3[理学—高分子化学]