Sesquiterpenoids from a South China Sea gorgonian Menella sp.  

南海小月柳珊瑚中倍半萜类化学成分研究(英文)

作　　者：郭志琴[1] 柴兴云[1,2] 杨斌[2] 周雪峰[2] 刘永宏[2] 屠鹏飞[1,3] 

机构地区：[1]北京中医药大学中药现代研究中心,北京100029 [2]中国科学院南海海洋研究所海洋生物资源可持续利用重点实验室,广东广州510301 [3]北京大学医学部天然药物及仿生药物国家重点实验室,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》2013年第3期282-285,共4页中国药学（英文版）

基　　金：Post-doctoral Science Foundation of China(Grant No.20080440784);Guangdong Province Natural Science Foundation(Grant No.9451030101003549)

摘　　要：To investigate the chemical constituents of a South China Sea gorgonian Menella sp., the isolation of ingredients was performed by solvent extraction and repeated chromatography on silica gel, Sephadex LH-20 and preparative TLC. The structures of isolated compounds were determined by spectroscopic analysis and comparison of 1H and 13C NMR data with those reported inliteratures. Three subergorane sesquiterpenoids and one suberosane sesquiterpenoid were isolated. Their structures were identified as subergorgic acid （1）, subergorgic acid methyl ester （2）, 2β-hydroxyl subergorgic acid methyl ester （3）, and suberosenol A （4）. All compounds were isolated from the genus Menella for the first time.对南海小月柳珊瑚Menellasp.的化学成分进行研究。应用反复硅胶柱层析、Sephadex LH-20柱色谱和制备薄层等多种色谱方法进行分离和纯化。从中分离得到3个subergorane倍半萜和1个suberosane倍半萜化合物,利用波谱分析技术和文献比对等方法确定化合物的结构,分别为柳珊瑚酸(1),柳珊瑚酸甲酯(2),2β-羟基柳珊瑚酸甲酯(3)和suberosenol A(4)。以上化合物均为首次从小月柳珊瑚属(Menella)中分离得到。

关 键 词：GORGONIAN Menella sp. SESQUITERPENOID Plexauridae 

分 类 号：R284[医药卫生—中药学]