常规IVF受精失败后补救ICSI与直接ICSI的对比研究  

Comparative study of remedy ICSI underwent conventional IVF fertilization failure and directly ICSI

作　　者：余相[1] 

机构地区：[1]广东省惠州市中心人民医院生殖医学中心,广东惠州516001

出　　处：《中国当代医药》2013年第15期27-28,共2页China Modern Medicine

摘　　要：目的研究常规体外受精失败或受精率低于20%时实施补救性ICSI的妊娠结局。方法常规体外受精培养18h后受精失败或卵母细胞受精率低于20%的16个周期(共16例)为观察组,直接ICSI的39个周期(共39例)为对照组,比较两组患者的结局。结果两组患者的可移植胚胎率及卵裂率差异无统计学意义(P>0.05)。对照组患者正常受孕率[(80.4±14.8)%]显著高于观察组[(70.4±14.5)%],差异具有统计学意义(P<0.05)。临床妊娠率方面,对照组为38.5%,观察组进行补救ICSI后,有1例女性成功分娩1个健康婴儿。结论常规进行体外受精失败或受精率低于20%的患者进行补救性ICSI,临床妊娠率较低,有待进一步研究以改善妊娠结局。Objective To study the pregnancy outcome of remedial ICSI underwent conventional in vitro fertilization failure or fertilization rate was lower than 20%. Methods The 16 cycles （16 cases） underwent fertilization failure 18 hours after conventional IVF culture or oocyte fertilization rate was less than 20% were as observation group, 39 cycles （39 cas- es） for directly ICSI were as control group, pregnancy outcome in the two groups were compared. Results About trans- ferred embryos rate and cleavage rate in the two groups, the difference was no statistically significant （P 〉 0.05）. Nor- mal pregnancy rate in the control group （80.4＋14.8）% was significantly higher than that in the observation group （70.4＋ 14.5） % （P 〈 0.05）, the difference was statistically significant （P 〈 0.05）. The clinical pregnancy rate in the control group was 38.5%. After remedy ICSI in the observation group, there was 1 case women successfully deliver a healthy baby. Conclusion Clinical pregnancy rate of remedial ICSI for conventional IVF failure or fertilization rate is less than 20% is lower, we must carry out further research to improve pregnancy outcomes.

关 键 词：补救ICSI 卵胞浆内单精子注射 体外受精 研究 

分 类 号：R711.6[医药卫生—妇产科学]