110例新生儿感染早期诊断的临床研究  

Clinical study of early diagnosis of 110 cases of neonatal infection

作　　者：王依[1] 魏谋 陈群娣[1] 

机构地区：[1]广东省博罗县人民医院儿科,广东博罗516100 [2]广州市妇女儿童医疗中心,广东广州510623

出　　处：《中国当代医药》2013年第15期86-87,共2页China Modern Medicine

基　　金：广东省广州市医药卫生科技项目(20121A011075)

摘　　要：目的研究在新生儿感染早期诊断中PCT、hs-CRP的临床意义。方法截取本院2012年1月～2013年1月共110例新生儿,按感染病原分为细菌组、支/衣原体组、病毒组,并截取30名健康新生儿作对照组,对比4组患者间临床资料的差异性。结果支/衣原体、细菌、病毒感染患儿血清hs-CRP、PCT、WBC计数对比健康儿童组升高(P<0.01),同时细菌感染组PCT、hs-CRP水平升高最为明显,PCT、hs-CRP联合诊断中,敏感度、特异度均较PCT、WBC计数联合,hs-CRP、WBC计数联合诊断分别高出29.6%、26.9%,27.8%、58.3%。结论使用PCT、hs-CRP、WBC计数可作为新生儿感染诊断的有效指标,将hs-CRP、PCT联合诊断中,特异度、敏感度最为满意。Objective To study the clinical significance of PCT and hs-CRP in the early diagnosis of neonatal infection. Methods A total of 110 neonates born in our hospital from January 2012 to January 2013 were selected and divided into the bacteria group, the mycoplasma/chlamydia group and the virus group according to the infection pathogen and 30 healthy neonates were selected as the control group. The differences of the four groups in the clinical data were compared. Results The serum hs-CRP, PCT and WBC count of the bacteria, mycoplasma/chlamydia and virus groups increased compared to those of the healthy children group （P 〈 0.01）, of which the PCT and hs-CRP levels of the bac- terial group increased most obviously. The sensitivity and specificity of the combined PCT and hs-CRP diagnosis were 29.6% and 26.9% higher than those of the combined PCT and WBC count diagnosis and 27.8% and 58.3% higher than those of the combined hs-CRP and WBC count diagnosis. Conclusion PCT, hs-CRP and WBC count can serve as the effective indicators for the diagnosis of neonatal infection and the combined hs-CRP and PCT diagnosis shows the most satisfactory specificity and sensitivity.

关 键 词：超敏C反应蛋白 降钙素原 感染 新生儿 

分 类 号：R722.13[医药卫生—儿科]