不同剂量比阿培南治疗重症肺炎效果观察  

Clinical Observation of Biapenem in Treatment of Severe Pneumonia with Different Doses

作　　者：王永进[1] 张霞[1] 何钢[1] 闫伟敏[1] 张力[1] 刘惠敏[1] 

机构地区：[1]解放军白求恩国际和平医院重症医学科,石家庄050082

出　　处：《临床误诊误治》2013年第5期15-17,共3页Clinical Misdiagnosis & Mistherapy

摘　　要：目的评价不同剂量比阿培南治疗重症肺炎的效果和安全性。方法将72例重症肺炎随机分为常规剂量组(38例)和大剂量组(34例)。常规剂量组静脉滴注比阿培南0.3 g,12 h 1次,疗程7～14 d;大剂量组予比阿培南0.6 g,方法、疗程同常规剂量组。疗程结束时评价临床效果及细菌清除率、药物不良反应。结果常规剂量组和大剂量组总有效率分别为52.6%和79.4%,细菌清除率分别为54.8%和82.1%,差异均有统计学意义(P<0.05)。常规剂量组不良反应发生率为5.3%,大剂量组为17.6%,大剂量组不良反应发生率高于常规剂量组,但差异无统计学意义(P>0.05),两组均未出现严重不良反应。结论比阿培南治疗重症肺炎效果确切,大剂量效果优于常规剂量,且患者对比阿培南耐受性良好。Objective To evaluate the efficacy and safety of biapenem in treatment of severe pneumonia with different doses. Methods A total of 72 patients with severe pneumonia were randomly divided into the conventional dose group （n =38） and large dose group （n = 34）. The conventional dose group was treated with intravenous drip of 0. 3 g biapenem every 12 hours for 7 -14 days; while the large dose group was treated with 0.6 g biapenem of intravenous drip every 12 hours for 7 - 14 days. The clinical effect, bacteria clearance and adverse drug reaction were evaluated at the end of treatment. Results The total effective rates in conventional dose group and large dose group were 52.6% and 79.4% respectively, bacteria removal rates were 54.8% and 82.1% respectively, and the differences between the two groups were statistically significant （P 〈0.05）. The incidence rates of adverse reaction were 5.3% in conventional dose group and 17.6% in high-dose group, but the differences between the two groups were not statistically significant （P 〉 0.05）. There were no serious adverse reactions in the two groups. Conclusion Biapenem may effectively treat severe pneumonia. The effect of large dose is better than that of conventional dose. Patients＇tolerance on biapenem is normal.

关 键 词：肺炎 比阿培南 剂量 

分 类 号：R563.1[医药卫生—呼吸系统]