Fox家族在非洲爪蟾胚胎发育中的表达模式及作用  

Expression patterns and functions of forkhead transcription factors in embryonic development of Xenopus laevis

作　　者：申姗姗[1] 任斐[2] 陈晓虹[1] 

机构地区：[1]河南师范大学生命科学学院,河南新乡453007 [2]河南科技学院动物科学学院,河南新乡453003

出　　处：《广东农业科学》2013年第7期136-138,I0001,共4页Guangdong Agricultural Sciences

摘　　要：Forkhead转录因子家族具有一段高度保守的DNA结合结构域,具有转录活化、抑制作用,能够通过信号转导和转录调控对细胞周期、分化、代谢、凋亡、免疫及生长发育等产生影响。非洲爪蟾是胚胎学研究中主要的两栖类动物模型,很多Fox家族成员对非洲爪蟾胚胎发育的不同阶段都有影响。阐述了Fox家族的结构特征及其成员在非洲爪蟾胚胎发育过程中的时空表达模式,以及其对非洲爪蟾胚胎发育的影响。Forkhead/winged helix transcription factors act as transcription activator and/or repressor with a conserved DNA binding domain, wich could regulate cell differentiation, cell cycle, metabolism, apoptosis, immunization, development through various signaling pathways. Many forkhead transcription factors have different influences in embryonic development of Xenopus laevis which is a amphibian animal model in Embryology research. The paper reviewed structure characteristics, expression pattern and functions of Fox family in different embryonic development stages of X. laevis to understand the molecular mechanism involved in embryonic development of frog or other animals.

关 键 词：Forkhead转录因子 胚胎发育 时空表达模式 非洲爪蟾 

分 类 号：Q953.3[生物学—动物学]