分析我院抗菌药的管理策略与应用情况  

Analysis the management strategies and applications of antibiotics in our hospital

作　　者：菅凌燕[1] 何晓静[1] 于莹[1] 刘晓东[1] 张智洁[2] 

机构地区：[1]中国医科大学附属盛京医院药学部,沈阳110004 [2]中国医科大学附属盛京医院检验科,沈阳110004

出　　处：《中国临床药理学杂志》2013年第5期386-388,共3页The Chinese Journal of Clinical Pharmacology

基　　金：十二五科技"重大新药创制"专项基金资助项目(2012ZX09303015);辽宁省科学技术计划基金资助项目(2009225030)

摘　　要：目的制定积极有效的抗菌药管理策略以便促进抗菌药合理应用。方法分析我院呼吸科常用抗菌药用药频度及常见分离菌株对其耐药率的变化;临床药师参与抗菌药给药方案制定,优化静脉用抗菌药的调配流程。结果随着阿莫西林、左氧氟沙星用药频度的降低,肺炎克雷伯菌对其耐药率也显著降低,两者呈正相关;由于临床药师的参与,抗菌药不合理应用显著减少,抗菌药调配时间显著缩短。结论制定抗菌药管理策略及发挥临床药师的作用,可显著提高抗菌药合理用药水平。Objective To analyze the management strategies and appli- cations of antibiotics in our hospital. Methods The problems of antibi- otics prescriptions in respiratory department of our hospital, correlation between frequency of drug usage （ DDDs ） of antibiotics and resistant per- centage of bacterial isolates were analyzed, we also set special clinical pharmacists in department and guarantee them to institute dose regimen and improve dispensing flow of iv antibiotics. Results Following the fa- cilitating the antibiotics management strategies, antibiotics administration in our hospital was well regulated. With DDDs reduction of amoxicillin and levofloxacin, the percentage of Klebsiella pneumoniae resistant to them was also decreased. The time of dispensing antibiotics is significantly shortened. Conclusion We institute antibiotics management strategies and pay much attention to the roles of clinical pharmacists, and improve the level of antibiotics rational administration.

关 键 词：抗菌药 细菌耐药 管理策略 用药频度 

分 类 号：R978.1[医药卫生—药品] R954[医药卫生—药学]