慢性乙肝患者病毒量及血清学标志与病理指标的相关性研究  

Patients with chronic hepatitis b virus and serological sign and pathological correlation studies

作　　者：李雄[1] 罗爱华[1] 吴辉耀[1] 吴祖扬[1] 张武[1] 

机构地区：[1]广东省高州市人民医院感染内科,525200

出　　处：《中国医疗前沿》2013年第8期25-26,共2页China Healthcare Innovation

摘　　要：目的研究慢性乙肝患者病毒量及血清学标志与病理指标相关性。方法选取29例乙肝患者,经确诊均具有血清学标志阳性反复肝功能异常,对其实施肝穿刺免疫组化和病理检查、血清肝炎病毒学监测、凝血功能检查和肝功能检查,采用荧光定量PCR方法对患者血清乙肝病毒DNA(HBV DNA)含量进行检测。结果经过对肝脏纤维化分期和炎症分级各组的血清HBV DNA定量水平进行比较发现,其差异均无统计学意义(P>0.05);HBV DNA的阴性和阳性患者在各项病理指标方面的差异也不具有统计学意义(P>0.05);对非乙肝患者与乙肝患者之间的相关数据指标进行比较后发现,其差异性不具有统计学意义(P>0.05)。结论随着临床病情的变化,慢性病毒性肝炎患者的血清学标志与肝脏纤维化病理也随之改变。采用血清学指标与肝组织活检的综合检测方法具有较高的临床诊断价值。Methods Select 29 patients with hepatitis b, confirmed have positive serological marker repeated abnormal liver function, liver puncture by the immunohistochemical and pathologic examination of serum hepatitis virology monitoring blood coagulation function and liver function tests,adopting fluorescence quantitative polymerase chain reaction（PCR） in serum of patients with hepatitis b virus DNA（HBV DNA） levels were detected. Through to the staging of liver fibrosis and inflammation grading comparison between groups of serum HBV DNA level of quantitative detection. The differences were not statistically significant（P〉0.05）, HBV DNA negative and positive in all patients with pathological indicators did not appear obvious difference, not statistically significant（P〉0.05）, For hepatitis b patients and hepatitis b patients between related data index found after comparison, the difference is not statistically significant（P〉0.05）. Conclusion As the change of clinical symptoms, the serological marker of patients with chronic viral hepatitis liver fibrosis pathological change. Adoption of serological indexes and liver biopsy comprehensive detection method has higher diagnosis value.

关 键 词：肝炎 乙型 病毒量 血清学 病理学 

分 类 号：R512.62[医药卫生—内科学]