重组乙型肝炎疫苗(酿酒酵母)免疫后15年的持久性效果研究  

Study on Antibody Persistence of the Neonatal after Vaccinated the Hepatitis B Vaccine Made by Recombinant Deoxyribonucleic Acid Technigues Saccharomyces Cerevisiae Yeast for 15 Years

作　　者：王存祯[1] 邢秀生[2] 王晓芳[3] 王海娇[3] 光明[3] 李虹[3] 常少英[3] 李太生[3] 安建会[3] 赵福民[3] 崔雁[3] 翟如芳[3] 

机构地区：[1]大同市疾病预防控制中心,山西大同037008 [2]阳泉市疾病预防控制中心,山西阳泉045000 [3]山西省疾病预防控制中心,太原030012

出　　处：《中国疫苗和免疫》2013年第2期147-149,182,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的探讨重组乙型肝炎(乙肝)疫苗(酿酒酵母)[Hepatitis B Vaccine Made by Recombinant Deoxyribonucleic Acid Techniquesin Saccharomyces Cerevisiae Yeast,HepB-SCY]新生儿免疫的持久性效果,为制订HepB免疫策略提供参考。方法对1995年出生、HepB-SCY全程免疫的儿童采集血清样本,检测乙肝病毒(Hepatitis B Virus,HBV)感染指标,追踪观察其免疫15年后的持久性效果。结果抗乙肝病毒表面抗原抗体[Antibody to HBV Surface Antigen(HBsAg),Anti-HBs]阳性[≥2.1毫国际单位/毫升(mIU/ml)]率、有效阳性(≥10mIU/ml)率及几何平均浓度随免疫年限的延长逐年下降,分别由基础免疫后1年时的92.08%、84.16%和29.2lmIU/ml,降为15年后的65.66%、40.40%和5.24mIU/ml;年均递减率分别为2.23%、4.78%和10.82%。Anti-HBs阳性率的下降速率较慢,而有效阳性率则较快,并显示各项指标的年均递减率随免疫后年限的延长呈明显缓慢的趋势,免疫的低阳性率状态可维持较长时间。HBsAg均阴性。结论儿童HepB-SCY免疫15年后,HBsAg皆阴性,Anti-HBs的低阳性率状态可存在较长时间,12～15年内暂不考虑Anti-HBs监测和再免疫。Objective To observe the antibody persistence of hepatitis B vccine made by recombinant deoxyribonucleic acid techniques in saccharomyces cerevisiae yast （HepB-SCY） among the neonatal. Provide the references for developing HepB-SCY immunization strategies. Method Collected serum samples of the children who were born in 1995 and completed full-course vaccination of HepB-SCY, detected infection indicators of hepatitis B virus （HBV）, for observing the effect of HepB-SCY among the children. Results Antibody to HBV surface antigen （HBsAg）（Anti-HBs）positive rate, the effective positive rate and geometric mean concentrations decreased year by year, decreased from 92.08%,$4.16%,29.21mIU/ ml to 65.66%,40.40%,5.24mIU/ml which were measured respectively in the first year and the 15th year after immunizations. The average annual decline rates were 2.23%,4.78%,10.82% respectively. Positive rate of Anti-HBs declined slowly and the effective positive rate declined rapidly. The average annual decline rates of various indicators were significantly slow with time. Speculate the state of low positive rate would be long time. All the HBsAg were negative. Conclusions There is no HBsAg infection in the children who immunized with HepB-SCY 15 years ago. The state of low Anti-HBs positive rate after kiepB- SCY immunizations would be long time. It need not to conduct the surveillance of the Anti-HBs and reimmunization within 12-15 years after vaccination of HepB.

关 键 词：重组乙型肝炎疫苗(酿酒酵母) 免疫持久性 

分 类 号：R512.62[医药卫生—内科学] R186[医药卫生—临床医学]