妊娠期可逆性后部白质脑病综合征患者乳酸脱氢酶的变化及意义  

CLINICAL VALUE OF LACTIC DEHYDROGENASE AS A BIOCHEMICAL MARKER IN PREGNANCY-INDUCED REVERSIBLE POSTERIOR LEUKOENCEPHALOLPATHY SYNDROME

作　　者：高惠丽[1] 孙静涛[1] 段丽[2] 轩维清[1] 李文会[1] 赵永艳[1] 王丽娟[1] 

机构地区：[1]河北省唐山市妇幼保健院妇儿医院,063000 [2]唐山市第九医院

出　　处：《中国煤炭工业医学杂志》2013年第5期714-716,共3页Chinese Journal of Coal Industry Medicine

基　　金：2011年唐山市科学技术研究与发展指导计划项目(编号111302061a)

摘　　要：目的探讨乳酸脱氢酶对妊娠期可逆性后部白质脑病综合征(RPLS)的变化及意义。方法回顾性分析住院患者126例,按妊娠期RPLS分为四组。正常产妇40例,轻度脑水肿44例,中度脑水肿34例,重度脑水肿8例。对四组的一般情况、乳酸脱氢酶及新生儿的情况进行对比分析。结果四组之间乳酸脱氢酶之间比较,差异有统计学意义(P<0.01);重度脑水肿孕妇LDH水平明显高于中度、轻度脑水肿孕妇,进一步两两比较,各组间孕妇LDH水平比较,差异均有统计学意义(P<0.05)。四组之间进行新生儿体重比较差异明显,有统计学意义(P<0.01)。不同LDH水平新生儿出生体重差异有统计学意义(P<0.05),孕产妇LDH的升高,新生儿的体重明显减低。结论乳酸脱氢酶能监测妊娠期可逆性后部白质脑病综合征的的病情进展,预测母婴预后。Objective To evaluate the clinical value of lactic dehydrogenase （LDH） in pregnancy- induce reversible posterior leukoencephalolpathy syndrome （RPLS）. Methods By reviewing and analyzing the clinical information of 126 patients, and then were divided into four groups with PRLS according to CT. Among of them, 40 patients was normal parturition;44 patients was light brain edema, 34 patients was midrange brain edema, 8 patients was heavy brain edema. Clinical characteristics in normal parturition and each subgroup were evaluated. Results To compared with LDH of four groups, which was statistical significance. （P〈0.01） The heavy brain edema was higher than other subgroup. The midrange brain edema was higher light groups, light groups was higher normal groups（P〈0.05）. To compared with newborn weight of four groups, which was statistical significance. To accompany with LDH heighten, newborn weight was obvious to lessen. （P〈0.01）. Conclusions Lactic dehydrogenase can reflect the severity of pregnancy induced reversible posterior leukoencephalolpathy syndrome and predict the prognosis of mother and newborn.

关 键 词：妊娠期 高血压 可逆性后部白质脑病综合征 X线计算机体层成像 乳酸脱氢酶 

分 类 号：R715.5[医药卫生—妇产科学]