面部念珠菌性肉芽肿1例  

A case of facial skin candidal granuloma

作　　者：朱文静[1] 李雪[1] 张旭焱 牟妍[1] 金仙花[1] 于凯[1] 李福秋[1] 夏建新[1] 

机构地区：[1]吉林大学第二医院皮肤科,长春130041 [2]内蒙古兴安盟蒙医院皮肤科,乌兰浩特137400

出　　处：《中国真菌学杂志》2012年第6期359-361,共3页Chinese Journal of Mycology

摘　　要：报道1例面部皮肤念珠菌性肉芽肿。患者女,14岁,口角糜烂10 a,面部散在斑块、结痂6 a。表现为面部大小不等圆形暗红色斑块,表面见黄褐色厚痂。额部皮损真菌镜检见大量菌丝,真菌培养鉴定为白念珠菌。组织病理见真皮浅中层弥漫性淋巴细胞、少量中性粒细胞浸润,并见多核巨细胞。PAS染色示角质层及痂皮内见大量菌丝,真皮多核巨细胞内见孢子。诊断为念珠菌性肉芽肿。给予灰黄霉素治疗2个月、卡介菌多糖核酸治疗6个月、伊曲康唑治疗7个月后,皮损减少,面部痂皮大部分脱落,目前仍在治疗中。A case of facial skin candidal granuloma was reported. A 14-year-old girl had a history of erosion around mouth for 10 years and interspersed plaques, scab on face for six years： Physical examination showed dark-red plaques with tan thick scab of vari-ous sizes on her face. Fungal microscope examination showed mass hyphae and that was identified as Candidas albicans. Histopatho- logical examination revealed infiltration of diffuse lymphocytes, sparse neutrophils and muhinucleated giant cells in upper dermis. Mass hyphae was found in cuticle and spores were found in muhinucleated giant cells by PAS stain. The diagnosis was made as can- didal granuloma. The lesions improved after treatment of two-month with Griseofulvin, six-month with BCG-PSN, seven-month with Itraconazole, most of the scab was dropped. The patient is still under treatment.

关 键 词：肉芽肿 念珠菌 白念珠菌 伊曲康唑 

分 类 号：R756.5[医药卫生—皮肤病学与性病学]