散发型克-雅病影像学特点与临床症状分析  

Imaging and clinical characteristics of sporadic Creutzfeldt-Jakob disease

作　　者：高岩[1] 张威[1] 冯娟[1] 韩顺昌[1] 

机构地区：[1]中国医科大学附属盛京医院第一神经内科,沈阳110004

出　　处：《中国现代神经疾病杂志》2013年第4期334-337,共4页Chinese Journal of Contemporary Neurology and Neurosurgery

摘　　要：散发型克雅病患者共计5例,临床主要表现为快速进展性痴呆,发病时间1～4个月。其中2例脑电图呈现特征性周期性同步放电,4例脑脊液14-3-3蛋白检测阳性。MRI扩散加权成像均显示皮质或基底节对称性或非对称性"彩带"样高信号,提示扩散加权成像对克雅病的诊断敏感且具有特异性,可作为临床首选检查方法。Five patients with sporadic Creutzfeldt- Jakob disease （sCJD） presented rapidly progressive dementia which were snbaeute onset from l to 4 months. Among these cases, periodic synchronous discharge （PSD） of electroencephalography （EEG） was seen in 2 patients. Besides, 4 patients obtained positive results in cerebrospinal fluid （CSF） analysis for 14- 3- 3 protein. The cranial MRI examination showed symmetrical or asymmetrical colored-ribbon-shaped high signals in cerebral cortex or basal ganglia by diffusion weighted imaging （DWI）, suggesting that DWI had high sensitivity and specificity for the diagnosis of sCJD as a preferred method in the clinical examination of sCJD.

关 键 词：克-亚综合征 磁共振成像 弥散 临床表现 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.9[医药卫生—诊断学]