不同配比的注射用头孢呋辛钠/他唑巴坦钠的体外抑菌作用考察  

Study on the Antibacterial Activity of Different Ratios of Cefuroxime Sodium/Tazobactam Sodium for Injection in vitro

作　　者：邢桂兰 李文广[3] 钟绍金 曾渝 符健 

机构地区：[1]海南省药物安全性评价研究中心,海口571199 [2]海南省药物临床前药理毒理学研究重点实验室,海口571199 [3]海南医学院微生物学和免疫学教研室,海口571199

出　　处：《中国药房》2013年第21期1935-1938,共4页China Pharmacy

基　　金：海南省重点科技计划资助项目(No.090215)

摘　　要：目的:观察不同配比的注射用头孢呋辛钠/他唑巴坦钠(CEF/TAZ)的体外抑菌效果,为寻找CEF与TAZ的最佳配比提供试验依据。方法:采用琼脂二倍稀释法,考察不同质量配比(1:1、2:1、4:1、8:1)的CEF/TAZ复方制剂对湖南长沙地区2009年6月-2011年6月的319株临床分离菌的体外抑菌效果,以50%最低抑菌浓度(MIC50)、MIC90及MIC抑菌范围为指标,并与单组分CEF、TAZ和阳性对照头孢噻肟钠/舒巴坦钠(CTX/SBT)、头孢曲松钠(CTRX)/SBT的抑菌效果进行比较。结果:对金黄色葡萄球菌和表皮葡萄球菌,无论其是否产β-内酰胺酶,4种配比的CEF/TAZ的抑菌效果均相对强于单组分和阳性对照,其中以CEF/TAZ(4:1、8:1)最明显;对产超广谱β-内酰胺酶(ESBLs)的细菌,CEF/TAZ(2:1、4:1)表现出较CEF/TAZ(1:1、8:1)、单组分和阳性对照更强的抑菌效果;对不产ESBLs的细菌,除CEF/TAZ(1:1)抗大肠埃希菌稍差外,其余3种配比的CEF/TAZ的抑菌效果均强于单组分和阳性对照。结论:CEF/TAZ以2:1、4:1质量配比时,对产与不产β-内酰胺酶或ESBLs的菌株均有较好的抑菌效果。OBJECTIVE：To observe the in vitro antibacterial activities of Cefuroxime sodium/tazobactam sodium（CEF/TAZ）for injection with different ratios,and to provide the experimental basis for the optimal ratio of CEF to TAZ.METHODS：The in vitro antibacterial activities of CEF/TAZ compound preparation with different quality ratios（1：1,2：1,4：1,8：1）against 319 pathogenic bacterias in Hunan Changsha area in 2009-06-2011-06 were investigated by agar dilution method using MIC50,MIC90 and MICrange.The antibacterial activities of CEF/TAZ compound preparation were compared with those of CEF,TAZ,CTX/SBT positive control and CTRX/SBT positive control.RESULTS：To Staphylococcus aureus and Staphylococcus epidermidis,the antibacterial activities of different ratios of CEF/TAZ compounds were better than others,specifically CEF/TAZ（4：1,8：1）,whether it produced β-lactamase or not.To ESBLs producing bacteria,CEF/TAZ（2：1,4：1）showed strong antibacterial activities,which were better than CEF/TAZ（1：1,8：1）,single component and positive control drug.To ESBLs non-producing bacteria,the antibacterial activities of different ratios of CEF/TAZ compounds were better than single component and positive control drug,except that of CEF/TAZ（1：1）was poor to Escherichia coli.CONCLUSIONS：CEF/TAZ（2：1,4：1）have sound antibacterial activities on β-lactamase or ESBLs producing strain and β-lactamase and ESBLs non-producing strain.

关 键 词：注射用头孢呋辛钠 他唑巴坦钠 体外抑菌 酶抑制剂 配比 

分 类 号：R965[医药卫生—药理学] R978.11[医药卫生—药学]