急性冠状动脉综合征血清NT-proBNP、hs-cTnT、hs-CRP和CK-MB检测及其临床意义  

Serum biomarker detection and its clinical significance in patients with acute coronary syndromes

作　　者：潘小成 

机构地区：[1]安吉人民医院检验科,浙江安吉313300

出　　处：《全科医学临床与教育》2013年第3期272-274,287,共4页Clinical Education of General Practice

摘　　要：目的探讨急性冠状动脉综合征患者血清生物标志物水平及其临床意义。方法选择急性冠脉综合征(ACS)患者157例,其中ST段抬高型急性心肌梗死(STEMI)82例及非ST段抬高型急性心肌梗死(NSTEMI)45例;不稳定心绞痛(UAP)30例、同期冠状动脉造影(CAG)阴性患者35例作为对照组。所有对象均检测NT-proBNP、hs-cTnT、hs-CRP及CK-MB并进行分析。结果 ACS综合征组血清NT-proBNP、hs-cTnT、hs-CRP及CK-MB水平均较对照组高,差异有统计学意义(Z分别=5.49、2.65、3.45、3.85,P均<0.05)。NT-proBNP与hs-cTnT和CK-MB呈正相关性(r分别=0.65、0.22,P均<0.05);NT-proBNP诊断ACS的ROC曲线下面积为0.857。结论 ACS患者血清生物标志物升高,联合检测对早期防控ACS具有积极的临床意义。Objective To explore serum biomarker levels and its clinical significance in patients with acute coronary syndromes. Methods Studied serum concentrations of four biomarkers （NT-proBNP, hs-cTnT, hs-CRP and CK-MB） in 157 patients with ACS, in which the ST segment elevation acute myocardial infarction （STEMI） were 82 cases and non ST segment elevation acute myocardial infaretion（NSTEMI ） were 45 cases; unstable angina pectoris（UAP）were 30 cases, 35 patients with negative coronary artery angiography （CAG） were as the control group. Results ACS syndrome group serum NT-proBNP, hs-cTnT, hs-CRP and CK-MB levels were higher than those of the control group, the differences were sta- tistically significant （Z=5.49,2.65,3.45,3.85 ,P〈0.05）. NT-proBNP displayed a strong correlation with hs-cTuT and CK- MB （r=0.65,0.22,P〈0.05）; the area under ROC curve of plasma NT-proBNP levels for diagnosis of ACS was 0.857. Conclusions Serum biomarkers elevated in patients with ACS; combined detection of serum biomarkers has a positive clinical significance for early prevention and control of ACS.

关 键 词：急性冠状动脉综合征 生物标志物 N端脑钠肽前体 超敏心肌肌钙蛋白T 

分 类 号：R541.4[医药卫生—心血管疾病]