CD_4分子结构和功能研究新进展  

New advances in research of molecular structure and function of CD4

作　　者：赵博渊[1] 徐菊梅 任天武 赵永聚[1] 

机构地区：[1]西南大学动物科技学院重庆市草食动物资源保护与利用工程技术研究中心,重庆400716 [2]甘肃省肃南裕固族自治县动物疫病预防控制中心,甘肃肃南734400 [3]甘肃省肃南裕固族自治县白银蒙古族乡农牧技术服务站,甘肃肃南734400

出　　处：《黑龙江畜牧兽医》2013年第6期35-37,共3页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(31172195);国家科技重大专项项目(2011ZX08008-004)

摘　　要：CD4分子属于免疫球蛋白超家族,其胞外区由4个免疫球蛋白样的结构域组成,在胸腺细胞发育的过程中,CD4分子的表达受多种因素的影响。由于该分子在T淋巴细胞发育、信号转导、细胞间通讯、细胞免疫应答和体液免疫应答的过程中发挥着重要作用,而被深入研究,对其功能有了初步的了解。成熟人类Th细胞表面表达的CD4(T4)受体,具有调控并识别抗原的能力,最新研究发现,CD4分子在精子介导转基因过程的外源DNA内化机制中还扮演着不可或缺的角色。CD4 molecule belongs to the immunoglobulin superfamily, and its extracellular region is composed of 4 immunoglobulin -like domains. CD4 molecule is affected by a variety of factors in the process of thymocyte development. Since CD4 molecule plays very import role in the process of T cells, signal transduction, cell communication, cellular and humoral immune responses, it has been studied deeply, leading to a preliminary understanding of its function. The CD4 （ T4 ） receptor of mature human cell surface expression has the ability of regulating and recoguizing antigens. A recent study finds that CD4 plays an integral role in the internalization mechanism of exogenous DNA during the process of sperm - mediated gene transfer.

关 键 词：CD4 结构 功能 人类免疫缺陷病毒(HIV) 精子介导(SMGT) 

分 类 号：Q343.15[生物学—遗传学]