手性膦小分子催化不对称反应的研究进展  

Progress in Enantioselective Phosphine Organocatalysis

作　　者：唐谦[1] 涂爱平[1] 邓真真[1] 胡梦莹[1] 钟为慧[1] 

机构地区：[1]浙江工业大学药学院绿色制药技术与装备教育部重点实验室,杭州310014

出　　处：《有机化学》2013年第5期954-970,共17页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21076194&21276238)资助项目~~

摘　　要：手性膦小分子催化的不对称反应是目前研究的热点之一,该类反应具有反应时间短、条件温和、催化活性高、环境友好等优点,符合绿色化学发展方向.对手性膦小分子催化的不对称Morita-Baylis-Hillman反应、Morita-Baylis-Hillman加成物的烯丙基位立体选择性取代反应、环加成反应、酯化反应,γ-加成反应以及其它重要的不对称反应进行简要的评述.Enantioselective phosphine organocatalysis has been a research frontier in the field of asymmetric catalysis. The comparable advantages, including short reaction time, mild reaction conditions, high catalytic activity, and environment be- nign, render the organocatalytic reaction to meet the development direction of green chemistry. This paper briefly reviews the recent advances in the development of chiral phosphine-catalyzed asymmetric reactions, such as Morita-Baylis-Hillman reac- tion, the asymmetric allylic substitution of Morita-Baylis-Hillman adducts, cycloaddition, esterification reaction, y-addition reaction and other asymmetric reaction.

关 键 词：手性膦小分子催化 Morita-Baylis-Hillman反应 不对称反应 

分 类 号：O643.32[理学—物理化学]