HA：RE(RE=Eu^3＋、Tb^3＋)纳米棒的制备与细胞毒性研究  

Synthesis of Europium or Terbium Doped Hydroxyapatite Nanorods and Their Cytotoxicity

作　　者：陶婷婷[1] 王进贤[1] 董相廷[1] 于文生[1] 李庆丽[1] 

机构地区：[1]长春理工大学化学与环境工程学院,应用化学与纳米技术吉林省高校重点实验室,长春130022

出　　处：《无机材料学报》2013年第5期557-560,共4页Journal of Inorganic Materials

基　　金：国家自然科学基金(50972020);博士点基金(20102216110002,20112216120003)~~

摘　　要：采用EDTA为模板,以CaCO3、NH4H2PO4、Eu2O3、Tb7O4、HNO3为原料,用NH3 H2O调节pH值,成功制备了掺铕羟基磷灰石(HA:Eu3+)及掺铽羟基磷灰石(HA:Tb3+)纳米棒,并采用XRD、场发射环境扫描电子显微镜、荧光光谱、酶联监测仪等对其荧光及细胞毒性进行了研究。结果表明:制备的HA:Eu3+纳米棒最强发射峰位于617 nm处,发射出明亮的红光;制备的HA:Tb3+纳米棒最强发射峰位于544 nm处,发射出明亮的绿光;细胞毒性研究表明HA:RE(RE=Eu3+、Tb3+)纳米棒是一种良好的生物示踪材料。Using CaCO3, Eu203, Tb704, HNO3 and NH4H2PO4 as starting materials, regulating pH value by NHa＇HO2, europium-doped and terbium-doped hydroxyapatite （HA：Eu^3＋/ HA：Tb^3＋） nanorods were prepared by hydrothermal method using EDTA as a template. The synthesized materials were systematically characterized by XRD and FESEM. Their luminescence properties and cytotoxicity were studied by fluorescence analysis and MTT assay, respectively. The results show that the main emission peaks of HA：Eu^3＋ and HA：Tb^3＋ nanorods occur at 617 and 544 nm, which can emit bright red and green light, respectively. The cell survival curves show that the prepared HA：Eu^3＋ and HA：Tb^3＋ nanorods can be used as ideal biological tracer materials.

关 键 词：HA:Eu3+ HA:Tb3+ EDTA 纳米棒 细胞毒性 

分 类 号：O61[理学—无机化学]