喉鳞癌中PTEN蛋白表达及临床意义  

Expression and clinical significance of PTEN protein in laryngeal squamous cell carcinoma

作　　者：张再兴[1] 付兴华[1] 

机构地区：[1]河北联合大学附属医院耳鼻咽喉科,063000

出　　处：《江苏医药》2013年第9期1078-1080,共3页Jiangsu Medical Journal

摘　　要：目的探讨第10号染色体缺失的磷酸酶和张力蛋白同源物基因(PTEN)蛋白在喉鳞癌组织中的表达及意义。方法采用流式细胞术检测PTEN蛋白在60例喉鳞癌组织标本(A组)和30例正常喉黏膜组织标本(B组)中的表达;A组再分为有淋巴结转移组(A1组,12例)和无淋巴结转移组(A2组,48例)。结果 A组PTEN蛋白表达明显低于B组(P<0.01);临床Ⅰ+Ⅱ期喉鳞癌PTEN蛋白表达量高于Ⅲ+Ⅳ期(P<0.05);高中分化喉鳞癌PTEN蛋白表达高于低分化喉鳞癌(P<0.05);A1组患者的PTEN蛋白表达量低于A2组(P<0.01);喉鳞癌生存期大于5年的患者PTEN蛋白阳性表达率高于生存期小于5年的患者(P<0.01)。结论 PTEN蛋白可能是评价喉鳞癌预后的一个重要指标。Objective To investigate the expression and clinical significance of phosphatase and tensin homologue deleted on chromosome ten（PTEN） protein in laryngeal squamous cell carcinoma （LSCC）. Methods The expression of PTEN protein was detected wiith flow cytometry in 60 cases of LSCC samples（group A） and 30 cases of normal laryngeal mucosa tissues （group B）. Group A was subdivided into two groups of A1 （12 case, with lymph node metastasis） and A2 （48 cases, without lymph node metastasis）. Results The expression of PTEN protein in group A was lower than that of group B（P〈0. 01）, which was also lower in group A1 than that in group A2 （P〈0. 01）. The expressions of PTEN protein in clinical stages of Ⅰ and Ⅱ , well and moderate differentiation were higher than those of stages of Ⅲ and Ⅳ stages or lower differentiation（P〈0. 05）. The positive rate of PTEN protein in the patients survived beyond five years was higher than that of less than five years （P〈0. 01）. Conclusion PTEN protein may be an important indicator for evaluating the prognosis of the patients with LSCC.

关 键 词：喉鳞状细胞癌 第10号染色体缺失的磷酸酶和张力蛋白同源物基因蛋白 

分 类 号：R767[医药卫生—耳鼻咽喉科]