固醇调节元件结合蛋白1及其靶基因网络  

Sterol regulatory element binding protein 1 and its target gene networks

作　　者：汤晓丽[1,2] 邓立彬[3] 林加日[3] 张伟龙[3] 刘双梅[1] 魏懿[3] 梅普明[3] 汪雁[3] 梁尚栋[1] 

机构地区：[1]南昌大学医学院生理学教研室,南昌330001 [2]南昌大学医学院生物化学教研室,南昌330001 [3]南昌大学转化医学研究院,南昌330001

出　　处：《遗传》2013年第5期607-615,共9页Hereditas（Beijing)

基　　金：国家自然科学基金项目(编号:81260021;81200631;81171184;31060139;30860086;30660059);江西省科技支撑计划-社会发展支撑计划重点项目(编号:2010BSA09500);江西省青年科学基金资助项目(编号:20114BAB215019)资助

摘　　要：固醇调节元件结合蛋白1(Sterol regulatory element-binding protein 1,SREBP-1)是重要的核转录因子之一,能调控内源性胆固醇、脂肪酸、甘油三酯和磷脂合成所需酶的表达,以维持血脂动态平衡。研究表明,SREBP-1及其靶基因网络的异常可引起胰岛素抵抗、Ⅱ型糖尿病、心功能紊乱、血管并发症和肝脂肪变等一系列代谢性疾病。近年高通量组学技术的发展极大扩展了对SREBP-1靶基因及其转录调控模式的了解。文章对SREBP-1蛋白结构、活化过程、DNA结合位点及其调控的靶基因等方面的研究进展进行了综述,并着重介绍了基于组学数据的转录调控网络的构建,这将有助于更好的认识SREBP-1在脂类代谢中的作用,为深入探讨脂质代谢性疾病的治疗提供新线索。Sterol regulatory element binding protein 1 （SREBP-1） is one of the important nuclear transcription factors. SREBP-1 can maintain lipids dynamic equilibrium by regulating the expression of enzymes required for synthesis of endogenous cholesterol, fatty acids, triglycerides and phospholipids. Anomalies of SREBP- 1 and its target genes can cause a series of metabolic diseases such as insulin resistance, type Ⅱ diabetes, heart dysfunction, vascular complications and hepatic steatosis. In these years, the development of high-throughput technologies has greatly expanded our knowledge about SREBP-1 target genes and the pattern of transcriptional regulation. Here we reviewed recent research progress of SREBP-1, with a focus on the protein structure, activation process, DNA binding sites and target genes. Most importantly, we showed the transcriptional regulatory networks based on omics datasets, which will contribute to a better understanding of the role of SREBP-1 in lipid metabolism and provide new clues for the treatment of lipid metabolism disorders.

关 键 词：固醇调节元件结合蛋白1 靶基因 基因调控网络 脂类代谢 

分 类 号：Q75[生物学—分子生物学]