Modeling of micropipette aspiration and optical tweezers stretching of erythrocytes with or without Malaria parasite  

作　　者：Guyue Jiao Ruojing Zhang 

机构地区：[1]School of Aerospace Engineering and Applied Mechanics Tongji University

出　　处：《Theoretical & Applied Mechanics Letters》2013年第3期59-64,共6页力学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (11072178,11172214);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry,and Shanghai Leading Academic Discipline Project (B302)

摘　　要：The erythrocytes play an important role in the human body. The healthy erythrocytes can undergo extremely large deformation while passing through small capillaries. Their infection by Malaria Plasmodium falcipurum （P.f.） will lead to capillary blockage and blood flow obstruction. Many experimental and computational methods have been applied to study the increase in stickiness and decrease in deformability of the Malaria （P.f.） infected erythrocytes. The novelty of this paper lies in the establishment of an multi-component model for investigating mechanical properties of Malaria （P.f.） infected erythrocytes, especially of their enclosed parasites. Finite element method was applied to simulate the erythrocytes＇ deformation in micropipette aspiration and optical tweezers stretching using the computational software ABAQUS. The comparisons between simulations and experiments were able to quantitatively conclude the effects of stiffness and stickiness of the parasitophorous vacuole membrane on the cells＇ deformation, which could not be obtained from experiments directly.The erythrocytes play an important role in the human body. The healthy erythrocytes can undergo extremely large deformation while passing through small capillaries. Their infection by Malaria Plasmodium falcipurum （P.f.） will lead to capillary blockage and blood flow obstruction. Many experimental and computational methods have been applied to study the increase in stickiness and decrease in deformability of the Malaria （P.f.） infected erythrocytes. The novelty of this paper lies in the establishment of an multi-component model for investigating mechanical properties of Malaria （P.f.） infected erythrocytes, especially of their enclosed parasites. Finite element method was applied to simulate the erythrocytes＇ deformation in micropipette aspiration and optical tweezers stretching using the computational software ABAQUS. The comparisons between simulations and experiments were able to quantitatively conclude the effects of stiffness and stickiness of the parasitophorous vacuole membrane on the cells＇ deformation, which could not be obtained from experiments directly.

关 键 词：cell mechanics Malaria infected red blood cells micropipette aspiration finite elementmethod HYPERELASTICITY 

分 类 号：R382[医药卫生—医学寄生虫学]