以糖化血红蛋白分层分析益糖康治疗痰热互结型代谢综合征患者各代谢指标的变化  

HbA1c Stratified Analysis of Yitangkang Effect on Metabolic Parameters for Treating Metabolic Syndrome Patients with Phlegm Heat Interties

作　　者：刘小溪[1] 石岩[2] 王莉[1] 杨宇峰[2] 

机构地区：[1]辽宁中医药大学附属医院内分泌科,沈阳110032 [2]辽宁中医药大学,沈阳110032

出　　处：《中国实验方剂学杂志》2013年第11期287-292,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"十一五"科技支撑计划项目(2007BAI20B103)

摘　　要：目的:以糖化血红蛋白(HbA1c)6.5%为切点,分层统计分析益糖康治疗痰热互结型并有糖调节受损(IGR)的代谢综合征(MS)患者糖代谢、脂代谢及血压、体重指数(BMI)等指标的变化,旨在明确在不同HBA1c分层下益糖康对患者各项代谢指标的改善作用及临床疗效。方法:研究采用多中心、随机、双盲、安慰剂对照的原则选择符合诊断标准的并有IGR的MS患者165例,随机分为两组。治疗组应用益糖康,对照组应用安慰剂,疗程12周,治疗前后检测HBA1c、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血压、体重指数(BMI)等指标,并以HbA1c为6.5%分层统计各项代谢指标的变化。结果:痰热互结型并IGR的MS患者以HbA1c<6.5%为主,120例占总数的72.7%;无论HbA1c高于或低于6.5%,益糖康均可降低患者2 h PG及收缩压及舒张压(P<0.05);HbA1c≥6.5%时益糖康可以降低患者FPG,HbA1c,TG水平(P<0.05);HbA1c<6.5%时益糖康可以降低患者TC水平(P<0.05)。结论:益糖康可以明显改善合并有IGR的MS患者的糖脂代谢指标,对血压及体重指数也有良好的调节作用;并对不同的HbA1c分层有不同的作用。Objective： To investigate the clinical effect of Yitangkang by analyzing the changes in the glucose metabolism, lipid metabolism and blood pressure, body mass index （BMI） and other parameters for patients with impaired glucose regulation （IGR）, metabolic syndrome （MS） and phlegm-heat interties using glycosylated hemoglobin （HbA1c） 6.5% as the cut off point. Method： Multi-centered 165 patients with MS and IGR were selected and divided into two groups （n=82）, patients in treatment group were given Yitangkang, patients in control group（n=83） were given placebo, all the patients were treated for 12 weeks, the HbA1c, fasting plasma glucose（FPG）, postprandial 2 h glucose, total glycerin （TG）, total cholesterol （TC）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C）, blood pressure（BP）, BMI before and after treatment were detected and statistical analyzed with HbA1c 6.5% as the cutoff point. Result： Patients with IGR, MS and phlegm-heat interties accounted 120 cases （75%） as HbA1c〈6.5%. The 2 hPG and BP of treatment group were decreased （P〈0.05） no matter the HbA1c level. FPG and TG could decrease by Yitangkang when HbA1c≥6.5%; TC levels could decrease by Yitangkang when HbA1c〈6.5% （P〈0.05）. Conclusion： Yitangkang, the Chinese herbal compound, can significantly improve glucose and lipid metabolism parameters for patients with IGR and MS, and can regulate the BP and BMI and also plays different roles at different HbA1c layers.

关 键 词：益糖康 糖化血红蛋白 糖调节受损 代谢综合征 血糖 血脂 

分 类 号：R287[医药卫生—中药学]