健脾化瘀解毒法对慢性萎缩性胃炎的临床疗效及对细胞周期蛋白E表达的影响  

Effect of the Treatment of Jianpi Huayu Jiedu for Patients with Chronic Atrophic Gastritis and its Influence on Cyclin E Protein Expression

作　　者：郭亚蕾[1] 饶晶[1] 潘华峰[1] 方家[2] 

机构地区：[1]广州中医药大学,广州510405 [2]江西省中医院,南昌330004

出　　处：《中国实验方剂学杂志》2013年第11期292-295,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省自然科学基金项目(S2011010003685)

摘　　要：目的:观察健脾化瘀解毒法对慢性萎缩性胃炎(CAG)癌前病变(PLGC)病人的疗效以及对细胞周期蛋白E(Cyclin E protein)表达的影响。方法:60例患者随机分为治疗组和对照组各30例。另设10例健康对照组。对照组采用胃复春片,4片/次,3次/d。治疗组采用健脾化瘀解毒方治疗,常规水煎服分3次服用,1剂/d。疗程均为24周。观察两组的临床疗效、胃镜、病理及幽门螺杆菌(HP)的改变;测定Cyclin E蛋白的表达量。结果:治疗组总有效率93.33%,对照组总有效率86.67%,差异不明显;治疗组胃镜总有效率(80.00)优于对照组(60.00%)(P<0.05);治疗组病理疗效总有效率(76.67%)优于对照组(60.00%)(P<0.05);治疗组HP根除率(68.18%)明显优于对照组(21.05%)(P<0.05);两组治疗后Cyclin E蛋白的表达均降低,治疗组降低更显著(P<0.01)。结论:健脾化瘀解毒法能提高CAG胃镜及病理疗效,HP根除率高;健脾化瘀解毒法能调节Cyclin E蛋白的表达,从而阻止胃癌前病变发展。Objective： To observe the clinical effect of the treatment of Jianpi Huayu Jiedu for the patients with chronic atrophic gastritis and its influence on the Cyclin E protein expression. Method： Sixty cases were divided into control group and treatment group （n=30 each） randomly. Another 10 persons were selected as the healthy controls. The patients in the control group were given Weifuchun tablets of 4 tid. The cases in the treatment group were received Jianpi Huayu Jiedu decoction （one decoction divided taken 3 times daily）. Clinical effect, endoscopic images, pathological changes and the effect on helicobacter pylori （HP） were observed in each group. The expression of Cyclin E protein in every group was investigated using immunohistochemistry. Result： The total effect in treatment group was 93.33%, that of the control group was 86.67%, having no significant difference. The endoscopic images （80.00%）, pathological changes （76.67%） and the HP eradication rate （68.18%） in the treatment group were better than those （60.00%, 60.00% and 21.05%） in the control group, having significant difference （P〈0.05）. The expression of Cyclin E protein was decreased after treatment in the both treatment group and control group, and the treatment group was also better than control group, with significant difference （P〈0.01）. Conclusion： The treatment of Jianpi Huayu Jiedu can influence the expression of the Cyclin E protein in the patients with precancerous lesion of gastric carcinoma, so it may prevent the development of precancerous lesion of gastric carcinoma.

关 键 词：健脾化瘀解毒法 慢性萎缩性胃炎 癌前病变 细胞周期蛋白E 

分 类 号：R287[医药卫生—中药学]