益气化瘀中药促进糖尿病大鼠难愈创面修复愈合的实验研究  

Experimental Study on Replenishing Qi and Dissipating stagnation Chinese Medicine in Promoting Wound Healing of Diabetic Rats

作　　者：徐杰男 阙华发[1] 唐汉钧[1] 高丹[1] 李星子[2] 诸炳骅[2] 

机构地区：[1]上海中医药大学附属龙华医院中医外科研究所,上海200032 [2]上海中医药大学基础医学院,上海201203

出　　处：《新中医》2013年第6期153-156,共4页New Chinese Medicine

基　　金：国家自然科学基金项目(编号:81173266);国家自然科学基金青年科学基金项目(编号:81202697);上海市教育委员会预算内科研基金资助项目(编号:2010JW38);上海市卫生局中医药科研基金资助项目(编号:2010QL005A)

摘　　要：目的:观察益气化瘀中药治疗糖尿病大鼠难愈创面的疗效。方法:将43只雄性SD大鼠除正常对照组外,其余大鼠腹腔注射链脲佐菌素(STZ)建立糖尿病模型,随机分为模型组、益气化瘀中药组、氨基胍组,观察大鼠整体情况、体重。糖尿病造模当天于造模大鼠背部制造创面,观察创面愈合率、愈合时间。结果:模型组与正常对照组比较,大鼠整体情况差,体重无增长(P>0.05),创面愈合率降低(P<0.01),愈合时间明显延长(P<0.01);益气化瘀中药组、氨基胍组与模型组比较,大鼠创面愈合率均提高(P<0.01),愈合时间均缩短(P<0.01),且组间比较,差异无显著性意义(P>0.05),但益气化瘀中药组大鼠整体情况改善,体重增长(P<0.01,P<0.05),氨基胍组大鼠整体情况无明显改善,体重无明显增长(P>0.05)。结论:益气化瘀中药能明显改善糖尿病大鼠整体情况,促进糖尿病大鼠生长,明显促进糖尿病大鼠难愈创面修复愈合。Objective： To investigate the curative effects of Chinese medicine with the actions of replenishing qi and dissipating stagnation on diabetic ulcer rat. Methods： A total of 43 male SD rats were used for the experiment. The rats except for normal control group were injected intraperitoneally with streptozotocin to induce hyperglycemia. Diabetic rats were ran-domly divided into model group, Chinese medicine group and aminoguanidine group. The general health status and the body weight of rats were monitored. After inducing hyperglycemia, the back skin wound was established. The rate and the time of wound healing were observed. Results. Compared with the normal control group, the general health status became worse but the body weight of rats remained unchanged in model group（P〉 0.05）, the rate of wound healing was significantly lowered （P 〈 0.01） and the time of wound healing was obviously prolonged （P 〈 0.01）. In Chinese medicine group and aminoguanidine group, the rate of wound healing was significantly higher and the time of wound healing was obviously shorter than those in the model group（P 〈 0.01）, but the differences were insignificant between the two medication groups （P 〉 0.05）. Chinese medicine showed better effect on improving general health status and on increasing body weight（P〈 0.05, P〈 0.01 compared with the model group）, but aminoguanidine showed no effect on above indexes（P〉 0.05）. Conclusion： Chinese medicine with the actions of replenishing qi and dissipating stagnation can improve the general health status of diabetic rats, increase body weight, and obviously promote the wound healing of diabetic ulcer rat.

关 键 词：糖尿病溃疡 创面愈合 益气化瘀 大鼠 

分 类 号：R285.5[医药卫生—中药学]