生存素与卵巢癌的关系研究进展  

Research Progress in Relationship between Survivin Gene and Ovarian Carcinoma

作　　者：鲁静[1,2] 李海燕[2] 李晓红[2] 

机构地区：[1]保山中医药高等专科学校基础医学部,云南保山678300 [2]大理学院临床学院妇产科,云南大理671000

出　　处：《医学综述》2013年第10期1777-1779,共3页Medical Recapitulate

摘　　要：卵巢癌是女性生殖系统恶性肿瘤中病死率较高的疾病,只有多角度、深入的研究才能对该病的治疗提供更为广泛的空间,目前对卵巢癌研究的热点是生存素(Survivin基因)。现回顾生存素的结构和作用机制,阐述生存素在卵巢癌中的表达及其与该病预后、转移及血管生成的意义,总结目前较为热点的以生存素为靶位点进行基因修饰或干扰后卵巢癌的生长转移情况的临床研究,以期为卵巢癌的研究和治疗提供更广的思路。Ovarian carcinoma is one of the most common and lethal gynecological malignancies.Only a multi-angle and intensive research can provide more comprehensive sources for the treatment of the disease.Presently the therapeutic effects of survivin gene to the human ovarian carcinoma has been discussed extensively.Here is to make a review of the chemical structure and therapeutic mechanism of survivin gene,the expression of survivin gene in ovarian carcinoma and its clinical significance of prognosis,transfer and angiogenesis,the recent clinical research of gene modification with survivin gene for target sites and the changes of biology phenotype in tumor cells,in order to provide some new ideas in the research and treatment of ovarian carcinoma.

关 键 词：卵巢癌 生存素 预后分析 

分 类 号：R737.31[医药卫生—肿瘤]